Skip to main content

Table 6 Relationship between dependent variables (FEV1, FVC, number of lung lobes, chest CT score, BSI, FACED and e-FACED) and selected characteristics. Coefficients and 95% confidence intervals (CI) calculated with univariate and multivariable linear regression models

From: Exacerbations and Pseudomonas aeruginosa colonization are associated with altered lung structure and function in primary ciliary dyskinesia

Crude slopes(95% CI)
Independent
variables
FEV1(%) Predicted valueFVC (%) Predicted valueNumber of lung lobesChest CT scoreBSIFACEDe- FACED
Gender(males vs females)+  8.9 (− 5.3, +  23.2)+  0.1 (− 13.2, +  13.3)- 0.6 (−  1.4, +  0.2)- 4.6 (−  10.3, +  1.0)- 1.6 (− 4.0, +  0.7)- 0.6 (−  1.2, +  0.05)- 0.8 (−  1.9, +  0.3)
Age(10 years)- 5.4 (− 9.2, −  1.6)- 5.1 (− 8.6, −  1.6)+  0.4 (+  0.2, +  0.6)+  2.9 (+  1.5, +  4.3)+  0.9 (+  0.3, +  1.5)+  0.2 (+  0.03, +  0.4)+  0.4 (+  0.1, +  0.7)
BMI(Kg/m2)- 1.3 (− 2.9, +  0.3)- 1.2 (−  2.7, +  0.4)+  0.2 (+  0.1, +  0.2)+  1.0 (+  0.4, +  1.5)+  0.3 (+  0.1, +  0.6)+  0.1 (+  0.03, +  0.2)+  0.2 (+  0.1, +  0.3)
PA colonization Yes (# 15) vs No (# 43)- 4.6 (−  19.9, +  10.7)- 2.0 (−  16.0, +  12.0)+  1.0 (+  0.1, +  1.9)+  7.9 (+  1.8, +  14.0)+  4.2 (+  1.9, +  6.5)+  1.3 (+  0.7, +  1.9)+  1.7 (+  0.6, +  2.8)
Exacerbations
≥ 2 (# 36) vs
<  2 (# 22)
- 15.4 (−  30.3, −  0.5)- 8,2 (−  22.6, +  6.1)+  1.4 (+  0.7, +  2.6)+  9.6 (+  4.2, +  15.0)+  4.4 (+  2.3, +  6.6)+  0.9 (+  0.2, +  1.5)+  1.8 (+  0.7, +  2.8)
                                                                                                                 Slopes adjusted for gender, age, BMI, PA colonization, and exacerbations(95% CI)
Independent variablesFEV1(%) Predicted valueFVC (%)Predicted valueNumber of lung lobesChest CT scoreBSIFACEDe- FACED
Gender(males vs females)+  10.4 (−  3.5, +  24.3)+  1.0 (−  12.4, +  14.4)- 0.7 (−  1.3, +  0.1)- 4.9 (−  9.7, −  0.1)- 0.9 (−  2.8, +  1.0)- 0.4 (−  0.9, +  0.1)- 0.5 (−  1.5, +  0.4)
Age(10 years)- 4.9 (−  9.7, −  0.2)- 4.9 (−  9.4, −  0.4)+  0.2 (0.00, +  0.4)+  1.9 (+  0.2, +  3.6)+  0.4 (−  0.3, +  1.1)+  0.05 (−  0.1, +  0.2)+  0.1 (−  0.2, +  0.4)
BMI(Kg/m2)- 0.1 (−  2.0, +  1.7)+  0.03 (−  1.8, +  1.9)+  0.1 (+  0.01, + 0.2)+  0.4 (−  0.3, +  1.0)+  0.1 (−  0.1, +  0.4)+  0.1 (−  0.01, +  0.1)+  0.1 (−  0.03, +  0.2)
PA colonization Yes (# 15) vs No (# 43)+  0.5 (−  14.1, +  15.1)- 0.7 (−  14.6, +  13.3)+  0.4 (−  0.4, +  1.1)+  3.7 (−  1.7, +  9.1)+  2.8 (+  0.6, +  4.9)+  1.0 (+  0.4, +  1.6)+  1.1 (0.0, +  2.1)
Exacerbations ≥ 2 (# 36) vs <  2 (# 22)- 10.4 (−  25.2, +  4.4)- 4.7 (−  19.0, +  9.7)+  0.7 (+  0.1, +  1.4)+  5.2 (+  0.1, +  10.3)+  2.9 (+  0.8, +  5.0)+  0.4 (−  0.2, +  0.4)+  1.1 (+ 0.1, + 2.1)