Fig. 2

Patient 1. a Dental anomalies. Note the atypical shape of the permanent upper incisors (peg- shaped and notched; white arrows) and the areas of enamel demineralization (white and yellow-brown spots diffused and the lack of enamel –pitting-) on the vestibular surface of the inferior central incisor (white arrow). b Orthopantomography X-Ray (OPT-XR). The dental agenesis of the two upper canines was identified (canine position is indicated with stars) together with the dystopic eruptive direction (distoangulation) of the still included upper second premolar (red arrow). The germs of the wisdom teeth were not visible