Table 1 Clinical and laboratory characteristics of the two patients

 Age, years

13

13

 Sex

Male

Male

 Weight, kg

40.7

54

 Dose of TCZ

8 mg/kg

8 mg/kg

Potential cause

Underdone pork

Roast meat

Initial symptoms

Fever

Fever

Abdominal pain

Abdominal pain

Dizziness

Dizziness

Diarrhea

Diarrhea

Vomiting

Vomiting

 State

Unconsciousness

Dysphoria

 HR, /min

141

174

 RR, /min

41

56

 BP, mmHg

Undetectable

80/42

 MAP, mmHg

Undetectable^a

56^a

 SpO₂, %

76

83

 CRT, second

5

> 5

Laboratory findings

Normal value

 WBC, 10⁹/L

20.41

38.76

3.5–9.5

 Neutrophil, %

78

87

40–75

 Hemoglobin, g/L

118

121

115–150

 Platelet, 10⁹/L

458

399

125–350

 CRP, mg/L

107.13

95.9

0–3

 PCT, ng/ml

15.86

37.19

0–0.5

 ESR, mm/h

113

128

0–20

 Ferritin, μg/L

4118^b

5560^b

10–120

 Fibrinogen, g/L

2.6^b

3.01^b

1.8–4.0

 APTT, second

61.7

31.2

21–33

 PT, second

29

17.3

0–13

 AST, U/L

71.4^b

238.1^b

13–35

 ALT, U/L

94.3

982.3

7–40

 BNP, pg/ml

17,800

1230

0.1–1.0

 Creatinine, μmol/L

305.4^a

295.3^a

41–73

 Lactic acid, mmol/L

5.3

4.7

0–125

 IgG, g/L

3.98

6.8

8.6–17.4

 IgA, g/L

0.54

0.63

1.0–4.2

 IgM, g/L

0.32

1.3

0.5–2.8

 Blood culture

Salmonella enteritidis

Negative

Negative