Sub group |  | Cut-off value (μM*min/L) | RR (95% CI) | Number of studies | Number of participants in treatment group | Number of participants in control group | I2% |
---|---|---|---|---|---|---|---|
Administration route | IV Bu alone | ≤1350 versus> 1350 | 0.378 (0.158,0.906) | 3 | 106 | 30 | 0 |
 | ≤1500 versus> 1500 | 0.485 (0.171,1.377) | 3 | 129 | 17 | 0 | |
IV Bu + oral Bu/oral Bu | ≤1350 versus> 1350 | 0.363 (0.163, 0.805) | 4 | 101 | 31 | 0 | |
≤1500 versus> 1500 | 0.316 (0.087,1.145) | 2 | 34 | 11 | 0 | ||
VOD prophylaxis | Yes | ≤1350 versus> 1350 | 0.476 (0.120, 1.885) | 1 | 42 | 15 | NA |
 | ≤1500 versus> 1500 | 0.491 (0.109, 2.216) | 1 | 56 | 11 | NA | |
No | ≤1350 versus> 1350 | 0.349 (0.182, 0.670) | 6 | 165 | 46 | 0 | |
 | ≤1500 versus> 1500 | 0.380 (0.145, 0.994) | 4 | 107 | 17 | 0 |