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Table 4 Summary of subgroup analysis for the incidence of graft failure

From: Busulfan systemic exposure and its relationship with efficacy and safety in hematopoietic stem cell transplantation in children: a meta-analysis

Subgroup

 

Cut-off value (μM*min/L)

RR (95% CI)

Number of studies

Number of participants in treatment group

Number of participants in control group

I2%

Administration route

IV Bu

≤800 versus> 800

11.282 (0.930, 136.897)

2

2

36

0

≤900 versus> 900

9.718 (1.499, 62.989)

4

10

150

0

 

≤1000 versus> 1000

0.418 (0.030, 5.850)

2

23

15

0

≤1225 versus> 1225

0.139 (0.011, 1.729)

2

32

6

0

Oral Bu

≤800 versus> 800

3.904 (0.800,19.055)

2

20

42

0

 

≤900 versus> 900

2.613 (0.869,7.860)

3

49

66

0

 

≤1000 versus> 1000

2.189 (0.328,14.587)

2

39

23

0

 

≤1225 versus> 1225

1.197 (0.186,7.720)

2

46

16

0

  1. CI Confidence interval, NA Not applicable, IV Intravenous