Busulfan systemic exposure and its relationship with efficacy and safety in hematopoietic stem cell transplantation in children: a meta-analysis

Table 2 Outcomes and results of included studies

Reference	Type of AUC	Cut-off value	Reported outcome	Definition of graft failure or rejection	Definition of VOD
Faraci [20]	Initial	900	Graft failure	NR	Mcdonald criteria [30]
Okamoto [23]	Initial	800; 900; 1000; 1225; 1350; 1500	Graft failure; VOD	Failure to reach ANC > 0.5*10⁹/L by day 28 after transplantation	Mcdonald criteria [30]
maheshwari [13]	Initial and mean	1350; 1500	VOD	NR	McDonald criteria [31]
veal [24]	Mean	1350;1500	Hepatic toxicity or VOD	NR	Bearman criteria [32]
Michel [14]	Mean	900;1350;1500	VOD	NR	McDonald criteria [33]
Wall [15]	Initial, mean and Final	800; 900; 1000; 1225; 1350; 1500	Graft failure, VOD	Failure to reach ANC > 0.5*10⁹/L at any time after transplantation	Jones criteria [34]
vassal [16]	Mean	900;1350;1500	Graft failure; VOD	Failure to reach ANC > 0.5 *10⁹/L for three consecutive days by day 100 after transplantation	Jones criteria [34]
Bouligand [25]	Final	1350;1500	VOD	NR	McDonald criteria [33]
McCune [2]	Mean	900;1350	Graft failure; TRT	Failure to reach ANC > 0.5 *10 ⁹/L	Bearman criteria [32]
Bolinger [26]	Mean	800; 900; 1000; 1225;	Graft failure	No evidence of donor cells or initial evidence of donor engraftment followed by full autologous recovery	Bearman criteria [32]
Bolinger [17]	Initial and mean	800; 900; 1000; 1225;	Graft failure	No evidence of donor cells or initial evidence of donor engraftment followed by full autologous recovery	Bearman criteria [32]
Tran [29]	Mean	1350;1500	VOD	NR	Bearman criteria [32]
VASSAL [27]	Initial	1350;1500	VOD	NR	McDonald criteria [33]

NR Not reported, VOD Veno-occlusive disease, TRT Transplant-related toxicity

ISSN: 1471-2431