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Table 2 Cohort BoNTA treatment details

From: A prospective study investigating gross motor function of children with cerebral palsy and GMFCS level II after long-term Botulinum toxin type A use

Study ID number/

Age Group yrs. at assessment

CP type

Predominate tone

Comorbidity BMI

Current

GMFCS/MACS/CFCS

Details of BoNTA treatments

Lower limb surgery

GMFM

Total #LL

Age (yrs) first dose

Age (yrs) last dose

BoNTA dose u/kg

Mean (SD)

BoNTA

u/kg/muscle

Mean (SD)

Upper limb treatment

Total surgeries/

Age first surgery/type

No. BoNTA doses pre-surgery/post-surgery

Total score (SEM)

95% CI/Centile

#1/6–8

Hemiplegia

Dystonia

No 19.1

II/I/I

4

6

8

6.7 (0)

1.9 (0.3)

Yes

0

70.8 (1.6)

67.7–73.9/65th

#2/6–8

Hemiplegiaa

Spasticity

Autism 16.1

II/III/I

7

5

9

4.6 (1.1)

2.6 (0.3)

Yes

0

70.0 (1.5)

67–73/60th

#3/6–8

Hemiplegia

Spasticity

CHD 16.7

II/II/I

5

3

6

8.6 (2.6)

4.5 (0.9)

Yes

0

83.0 (2.6)

77.9–88/95th

#4/9–10

Hemiplegia

Spasticity

CHD 17.0

I/II/I

8

4

8

4.7 (0.9)

2.2 (0.7)

No

0

88 (3.4)

81.3–94.7/50th

#5/9–10

Hemiplegiaa

Spasticity

No 15.1

I/II/I

11

3

8

5.3 (0.6)

5.3 (0.6)

No

0

80.9 (2.5)

76.1–85.8/25th

#6/9–10

Hemiplegia

Dystonia

No 15.7

II/I/I

4

5

9

6.1 (1.2)

3.1 (0.6)

No

0

76.0 (1.9)

72.2–79.8/50th

#7/11–12

Hemiplegia

Spasticity

Autism 29.8

II/V/I

8

4

9

4.1 (1.5)

2.6 (0.4)

Yes

0

51.6 (1.2)

49.1–54.0/< 3rd

#8/11–12

Hemiplegia

Spasticity

Epilepsy 20.6

II/I/I

11

3

10

3.2 (1.1)

2.3 (0.5)

Yes

0

72.6 (1.6)

69.4–75.8)/55th

#9/11–12

Hemiplegiaa

Spasticity

No 18.2

I/II/I

18

2

10

4.4 (2.0)

4.4 (2.0)

Yes

0

81.9 (2.3)

77.3–86.5/25th

#10/11–12

Hemiplegia

Dystonia

Epilepsy, ID 16.0

I/II/I

9

5

11

4.8 (1.0)

2.4 (0.5)

No

0

89.7 (4.1)

81.6–97.8/55th

#11/13–15

Hemiplegiaa

Spasticity

Autism, ID 20.9

II/IV/IV

21

3

15

6.6 (2.5)

4.0 (1.8)

Yes

1/11 yrs. /Gait

Pre 15/Post 6

64.0 (1.4)

61.2–66.7/20th

#12/16 and over

Hemiplegia

Dystonia

No 18

I/I/I

13

10

15

2.1 (1.0)

2.1 (1.0)

Yes

0

96.0 (8.2)

79.0–100/85th

#13/16 and over

Hemiplegia

Spasticity

No 19.1

II/I/I

19

1

16

7.3 (3.5)

3.2 (1.4)

Yes

1/9 yrs./Gait

Pre 14/Post 5

75.3 (1.9)

71.7–79.0/ 65th

#14/6–8

Diplegiaa

Spasticity

No 16.6

II/I/I

12

3

7

4.6 (1.1)

2.6 (0.3)

Yes

0

74.7 (1.9)

70.9–78.6/85th

#15/6–8

Diplegia

Spasticity

No 15.2

II/I/I

11

1

8

16 (4.2)

4.3 (0.6)

No

0

78.3 (2.1)

74.1–82.4/90th

#16/9–10

Diplegia

Spasticity

LD 23

II/I/I

13

4

10

9.3 (2.1)

3.2 (0.7)

No

0

68.9 (1.5)

66.0–71.7/45th

#17/9–10

Diplegia

Spasticity

No 19.2

I/I/II

0

NA

NA

NA

NA

No

0

85.2 (2.8)

79.7–90.8/35th

#18/9–10

Diplegia

Spasticity

No 13.4

II/I/I

11

2

10

9.3 (3.2)

4.1 (0.8)

No

0

72.6 (1.6))

69.4–79.8/60th

#19/9–10

Diplegia

Spasticity

Autism 18.7

II/III/I

21

2

10

15.2 (2.2)

3.4 (0.7)

No

0

67.4 (1.5)

64.5–70.3/35th

#20/9–10

Diplegiaa

Spasticity

No 20.4

II/I/I

15

1

7

11.6 (2.1)

2.8 (0.6)

Yes

1/9 yrs./Gait

Pre 15

Post 0

68.9 (1.5)

66.0–71.7/40th

#21/11–12

Diplegia

Spasticity

ID, ILD 15

II/III/III

1

10

10

7.7 (NA)

3.9 (NA)

No

0

72.6 (1.6)

69.4–75.8/55th

#22/11–12

Diplegia

Spasticity

ID 18.1

II/I/II

7

8

11

10.0 (1.2)

1.8 (0.2)

No

0

78.3 (2.2)

73.9–82.7/75th

#23/11–12

Diplegiaa

Spasticity

PNI, LD 21

II/II/I

18

2

11

7.8 (4.9)

3.3 (1.0)

Yes

1/7 yrs./Gait

Pre 11

Post 7

61.5 (1.3)

59.0–64.0/10th

#24/11–12

Diplegia a

Spasticity

Epilepsy 24.4

II/II/II

17

2

10

13.3 (3.2)

3.5 (1.4)

No

0

70.0 (1.5)

67.0–73.0/40th

#25/11–12

Diplegia a

Spasticity

CHD 23

II/I/I

14

6

12

5.6 (2.3)

1.7 (0.6)

No

0

76.0 (2.1)

72.0–80.0/65th

#26/11–12

Diplegia a

Spasticity

No 28.6

II/I/I

2

7

9

1.4 (0.3)

1.4 (0.3)

No

0

74.2 (1.8)

70.7–76.7/60th

#27/13–15

Diplegia

Dystonia

No 20.2

II/III/II

27

2

16

9.0 (2.1)

2.8 (1.2)

No

0

86.5 (3.10

80.5–92.5/90th

#28/11–12

Diplegia

No 23.2

II/I/I

6

7

10

5.6 (2.3)

1.7 (0.6)

No

0

83.0 (2.5)

78.1–87.8/85th

  1. MACS Manual Ability Classification System, CFCS Communication Function Classification System, CHD congenital heart disease, ID intellectual disability, LD learning difficulties, ILD interstitial lung disease, PNI peripheral nerve injury, NA not applicable
  2. aPain reported present on brief pain inventory. Age at assessment listed as range to maintain deidentified status