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Table 5 Multivariate logistic regression model of factors associated with serious ADR (n = 1001 first admissions with documented exposure to ≥1 drug(s))

From: Serious adverse drug reactions at two children’s hospitals in South Africa

 nBivariate analysisMultivariate analysis
Unadjusted OR (95% CI)PAdjusteda OR (95% CI)P
Age categoryb
 Preterm neonate315.14 (1.34 to 19.7)0.0175.97 (1.30 to 27.3)0.021
 Term neonate & Infant490Referent
 Toddler1371.07 (0.292 to 3.96)0.9141.13 (0.295 to 4.33)0.858
 Early childhood1881.58 (0.567 to 4.42)0.3811.61 (0.521 to 4.97)0.408
 Middle childhood1143.62 (1.40 to 9.40)0.0083.63 (1.24 to 10.6)0.018
 Early adolescent413.79 (1.00 to 14.4)0.0502.88 (0.667 to 12.5)0.156
Sex
 Male564Referent   
 Female4371.08 (0.537 to 2.16)0.8320.894 (0.428 to 1.87)0.766
Hospital
 RXWMCH812Referent   
 RMMCH1890.953 (0.388 to 2.34)0.9170.938 (0.324 to 2.71)0.906
HIV category
 Negative840Referent   
 Infected295.44 (1.76 to 16.9)0.0033.87 (1.14 to 13.2)0.031
 Indeterminate1321.34 (0.502 to 3.57)0.5601.59 (0.502 to 5.05)0.429
Total drug count
 Per additional drug10011.09 (1.05 to 1.13)< 0.0011.08 (1.04 to 1.12)< 0.001
  1. aAdjusted for other variables in the model
  2. bPreterm neonate, born before 37 completed weeks’ gestation; term neonate, from birth to 27 days; infancy, 28 days to 12 months; toddler, 13 months to 24 months; early childhood, 25 months to 5 years; middle childhood, 6 years to 11 years; early adolescence, 12 years to 18 years
  3. ADR adverse drug reaction; OR odds ratio; RCWMCH Red Cross War Memorial Children’s Hospital; RMMCH Rahima Moosa Mother and Child Hospital