Skip to main content

Table 5 Multivariate logistic regression model of factors associated with serious ADR (n = 1001 first admissions with documented exposure to ≥1 drug(s))

From: Serious adverse drug reactions at two children’s hospitals in South Africa

 

n

Bivariate analysis

Multivariate analysis

Unadjusted OR (95% CI)

P

Adjusteda OR (95% CI)

P

Age categoryb

 Preterm neonate

31

5.14 (1.34 to 19.7)

0.017

5.97 (1.30 to 27.3)

0.021

 Term neonate & Infant

490

Referent

 Toddler

137

1.07 (0.292 to 3.96)

0.914

1.13 (0.295 to 4.33)

0.858

 Early childhood

188

1.58 (0.567 to 4.42)

0.381

1.61 (0.521 to 4.97)

0.408

 Middle childhood

114

3.62 (1.40 to 9.40)

0.008

3.63 (1.24 to 10.6)

0.018

 Early adolescent

41

3.79 (1.00 to 14.4)

0.050

2.88 (0.667 to 12.5)

0.156

Sex

 Male

564

Referent

   

 Female

437

1.08 (0.537 to 2.16)

0.832

0.894 (0.428 to 1.87)

0.766

Hospital

 RXWMCH

812

Referent

   

 RMMCH

189

0.953 (0.388 to 2.34)

0.917

0.938 (0.324 to 2.71)

0.906

HIV category

 Negative

840

Referent

   

 Infected

29

5.44 (1.76 to 16.9)

0.003

3.87 (1.14 to 13.2)

0.031

 Indeterminate

132

1.34 (0.502 to 3.57)

0.560

1.59 (0.502 to 5.05)

0.429

Total drug count

 Per additional drug

1001

1.09 (1.05 to 1.13)

< 0.001

1.08 (1.04 to 1.12)

< 0.001

  1. aAdjusted for other variables in the model
  2. bPreterm neonate, born before 37 completed weeks’ gestation; term neonate, from birth to 27 days; infancy, 28 days to 12 months; toddler, 13 months to 24 months; early childhood, 25 months to 5 years; middle childhood, 6 years to 11 years; early adolescence, 12 years to 18 years
  3. ADR adverse drug reaction; OR odds ratio; RCWMCH Red Cross War Memorial Children’s Hospital; RMMCH Rahima Moosa Mother and Child Hospital