From: Serious adverse drug reactions at two children’s hospitals in South Africa
n | Bivariate analysis | Multivariate analysis | |||
---|---|---|---|---|---|
Unadjusted OR (95% CI) | P | Adjusteda OR (95% CI) | P | ||
Age categoryb | |||||
Preterm neonate | 31 | 5.14 (1.34 to 19.7) | 0.017 | 5.97 (1.30 to 27.3) | 0.021 |
Term neonate & Infant | 490 | Referent | |||
Toddler | 137 | 1.07 (0.292 to 3.96) | 0.914 | 1.13 (0.295 to 4.33) | 0.858 |
Early childhood | 188 | 1.58 (0.567 to 4.42) | 0.381 | 1.61 (0.521 to 4.97) | 0.408 |
Middle childhood | 114 | 3.62 (1.40 to 9.40) | 0.008 | 3.63 (1.24 to 10.6) | 0.018 |
Early adolescent | 41 | 3.79 (1.00 to 14.4) | 0.050 | 2.88 (0.667 to 12.5) | 0.156 |
Sex | |||||
Male | 564 | Referent | |||
Female | 437 | 1.08 (0.537 to 2.16) | 0.832 | 0.894 (0.428 to 1.87) | 0.766 |
Hospital | |||||
RXWMCH | 812 | Referent | |||
RMMCH | 189 | 0.953 (0.388 to 2.34) | 0.917 | 0.938 (0.324 to 2.71) | 0.906 |
HIV category | |||||
Negative | 840 | Referent | |||
Infected | 29 | 5.44 (1.76 to 16.9) | 0.003 | 3.87 (1.14 to 13.2) | 0.031 |
Indeterminate | 132 | 1.34 (0.502 to 3.57) | 0.560 | 1.59 (0.502 to 5.05) | 0.429 |
Total drug count | |||||
Per additional drug | 1001 | 1.09 (1.05 to 1.13) | < 0.001 | 1.08 (1.04 to 1.12) | < 0.001 |