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Table 4 Multivariate Logistic Regression Models Predicting Odds of Neonatal Mortality within 28 days, Based on Assessment at Enrollment

From: Neonatal near-misses in Ghana: a prospective, observational, multi-center study

Variable Name

Model 1

(Major Near-Miss Categories)

Pseudo R2 = 0.0982

Model 2

(Aspects of Severe Complications)

Pseudo R2 = 0.0746

Model 3

(Aspects of Interventions)

Pseudo R2 = 0.0982

Model 4

(Aspects of Organ Dysfunction)

Pseudo R2 = 0.1517

Model 5

(Aspects of Investigations)

Psuedo R2 = 0.0133

Model 6

(Model with key predictors from previous models)

Pseudo R2 = 0.2176

Model 7

(Final Model)

Pseudo R2 = 0.2092

OR

P value

95% CI

OR

P value

95% CI

OR

P value

95% CI

OR

P value

95% CI

OR

P value

95% CI

OR

P value

95% CI

OR

P value

95% CI

Severe Complications

2.1

0.041*

1.0–4.1

                  

 Apgar Score < 7 at 5 min

   

1.3

0.396

0.7–2.3

               

 Gestational Age < 33 wks

   

6.4

< 0.001*

2.2–18.2

         

3.1

0.001*

1.6–6.0

3.0

0.001*

1.6–5.9

 Birthweight < 1800 g

   

0.5

0.194

0.2–1.4

               

 Suspected subgaleal bleed

   

1.3

0.576

0.5–3.5

               

 Major congenital abnormality

   

2.5

0.078

0.9–6.9

               

 Axillary temperature < 35 or > 39

   

1.9

0.023

1.1–3.6

         

1.7

0.09

0.9–3.3

   

 Severe jaundice that required blood exchange

   

2.2

0.265

0.6–8.4

               

 Surgery in the first week

   

1.0

1.0

0.9–10.7

               

Interventions

1.3

0.555

0.5–3.1

                  

 Resuscitation at delivery

      

0.9

0.737

0.4–1.8

            

 Resuscitation in NICU

      

2.0

0.069

0.9–4.1

            

 Chest compressions

      

9.6

0.007*

1.8–50.3

      

8.3

0.013*

1.6–44.4

7.2

0.019

1.4–37.5

 IV fluid bolus

      

1.3

0.426

0.7–2.6

            

 Any intubation

      

0.7

0.748

0.1–6.4

            

 Double phototherapy

      

1.1

0.932

0.3–3.2

            

 Double volume exchange blood transfusion

      

1.1

0.943

0.2–4.5

            

 Oxygen therapy

      

2.0

0.018*

1.1–3.7

      

0.8

0.468

0.4–1.6

   

 Caffeine citrate aminophylline

      

0.9

0.856

0.4–2.2

            

 Thermal protection

      

1.4

0.379

0.7–3.0

            

Organ System Dysfunction

3.8

< 0.001*

1.9–7.2

                  

 Cardiovascular

         

2.1

0.174

0.7–6.4

         

 Neurologic

         

2.9

< 0.001*

1.6–5.2

   

2.2

0.010*

1.2–4.3

2.3

0.008*

1.2–4.2

 Respiratory

         

4.5

< 0.001*

2.4–8.3

   

5.0

< 0.001*

2.4–10.1

4.6

< 0.001*

2.4–8.8

 Renal

         

1

(omitted)

–

   

3.0

0.152

0.6–13.8

   

 Gastroenterologic

         

0.4

0.435

0.04–4.2

         

Investigations

1.6

0.327

0.6–4.2

                  

 Hematocrit < 30% in first week

            

0.7

0.774

0.1–5.8

      

 Hemoglobin <10 gd/dl

            

4.3

0.044*

1.0–18

.4

6.9

0.003*

1.9–24.4

6.4

0.004*

1.8–22.8

 Blood culture done

            

0.9

0.649

0.5–1.6

      

 Blood culture positive

            

3.3

0.194

0.5–20.4

      
  1. *Significant at p < 0.05
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