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Table 2 Odds ratios for outcomes at 2 years of age (cerebral palsy (CP) and sensory deficiencies (blindness and deafness), and Ages and Stages Questionnaire (ASQ) results below threshold) amongst survivors of babies born at 27–28 weeks’ gestation in medium and high intensity units compared to low intensity units in France in 2011 using the Perinatal Activity Indicator based on babies born at 24–25 weeks’ GA

From: Intensity of perinatal care for extremely preterm babies and outcomes at a higher gestational age: evidence from the EPIPAGE-2 cohort study

ModelMedium intensityHigh intensity
 OR(95% CI)OR(95% CI)
Survival (among fetuses alive at maternal admission to hospital)
Baseline1.05(0.64 – 1.75)1.20(0.72 – 1.97)
Baseline + GA1.01(0.61 – 1.67)1.19(0.72 – 1.95)
Baseline + GA + multiple status0.99(0.60 – 1.64)1.15(0.70 – 1.89)
Baseline + extra variables0.96(0.54 – 1.71)1.12(0.63 – 2.00)
Survival without sensorimotor morbidity (among fetuses alive at maternal admission to hospital)
Baseline1.04(0.60 – 1.81)1.39(0.80 – 2.44)
Baseline + GA1.25(0.70 – 2.25)1.32(0.73 – 2.38)
Baseline + GA + multiple status1.20(0.67 – 2.14)1.27(0.70 – 2.28)
Baseline + extra variables1.09(0.59 – 2.01)1.16(0.62 – 2.16)
CP and sensory disability (among survivors)
Baseline2.04(0.73 – 5.75)1.53(0.54 – 4.37)
Baseline + GA2.11(0.73 – 6.11)1.54(0.52 – 4.50)
Baseline + GA + multiple status2.10(0.72 – 6.15)1.53(0.52 – 4.53)
Baseline + extra variables2.02(0.66 – 6.13)1.68(0.53 – 5.28)
ASQ below threshold (among survivors)
Baseline1.27(0.72 – 2.24)0.98(0.57 – 1.68)
Baseline + GA1.30(0.74 – 2.24)0.99(0.58 – 1.69)
Baseline + GA + multiple status1.28(0.72 – 2.28)0.97(0.56 – 1.67)
Baseline + extra variables1.35(0.76 – 2.40)1.01(0.58 – 1.76)
  1. 95% CI: 95% confidence interval. GA: gestational age. Extra variables: GA + multiple status + fetal sex + maternal age + family socioeconomic status + fertility treatment + chorioamnionitis + labour type + social security + small for GA + premature rupture of membranes. All analyses used multiple imputation
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