Table 4 Prognostic value of time dependent assessment of perioperative NT-proBNP on prolonged ICU stay (Two stage mixed effects model)

 Intercept

10.74

0.53

4.60×10⁴

1.64×10⁴ to 1.29×10⁵

<0.0001

 Before surgery

Reference

 1h after surgery

0.15

0.12

1.16

0.93 to 1.46

0.19

 12h after surgery

2.63

0.12

13.90

11.07 to 17.45

<0.0001

 36h after surgery

2.07

0.12

7.89

6.29 to 9.91

<0.0001

 Female

Reference

 Male

-0.13

0.086

0.88

0.74 to 1.04

0.12

 I/II

Reference

 III/IV

0.52

0.12

1.68

1.32 to 2.14

<0.0001

Age, d

-0.14

0.046

0.87

0.79 to 0.95

0.002

Weight, kg

-1.18

0.12

0.31

0.24 to 0.39

<0.0001

CPB time, min

0.41

0.10

1.51

1.23 to 1.85

<0.0001

ACC time, min

0.069

0.064

1.07

0.95 to 1.21

0.28

 NT-proBNP levels

0.38

0.11

1.46

1.19 to 1.84

0.001

 Before surgery

Reference

 1h after surgery

0.51

0.28

1.67

0.98 to 2.90

0.06

 12h after surgery

-1.91

0.76

0.15

0.03 to 0.65

0.01

 36h after surgery

1.59

0.55

4.92

1.72 to 14.89

0.004

 Female

Reference

 Male

0.09

0.19

1.09

0.76 to 1.60

0.64

 I/II

Reference

 III/IV

0.87

0.36

2.38

1.20 to 5.02

0.02

Age, d

-1.08

3.18

0.34

6.7×10^-4 to 1.82×10²

0.73

Weight, kg

1.03

0.92

2.81

0.45 to 17.25

0.26

CPB time, min

-2.33

1.75

0.097

0.003 to 3.56

0.18

ACC time, min

-0.69

3.17

0.50

0.001 to 258.16

0.83