Skip to main content

Table 1 Demographics and predictors of the severity of angioedema in children

From: Significant predictive factors of the severity and outcomes of the first attack of acute angioedema in children

VariablesChildren with a first attack of angioedema (N = 406)p-value
AllMild angioedema
(ED discharge)
N = 200
Moderate angioedema
(POU observation)
N = 97
Severe angioedema
(Hospital admission)
N = 109
No. (%)No. (%)No. (%)No. (%)
Gendera
 Male242 (59.6)107 (53.5)64 (66.0)71 (65.1)0.047
 Female164 (40.4)93 (46.5)33 (34.0)38 (34.9) 
Agea
 Infant64 (15.8)40 (20.0)6 (6.2)18 (16.5)< 0.001
 Preschool age193 (47.5)93 (46.5)38 (39.2)62 (56.9) 
 School age91 (22.4)39 (19.5)30 (30.9)22 (20.2) 
 Adolescent58 (14.3)28 (14.0)23 (23.7)7 (6.4) 
Possible etiologies of angioedemaa
 Medications93 (22.9)35 (17.5)37 (38.1)21 (19.3)< 0.001
 Foods99 (24.4)52 (26.0)28 (28.9)19 (17.4) 
 Various infections103 (25.4)42 (21.0)20 (20.6)41 (37.6) 
 Inhalants6 (1.5)4 (2.0)2 (2.1)0 (0) 
 Insects bites and stings12 (3.0)2 (1.0)0 (0)10 (9.2) 
 Contact materials2 (0.5)0 (0)2 (2.1)0 (0) 
 Unknown causes91 (22.4)65 (32.5)8 (8.2)18 (16.5) 
Clinical presentationsa
 Only skin lesions143 (35.2)87 (43.5)39 (40.2)17 (15.6)< 0.001
 Respiratory tract symptoms165 (40.6)76 (38.0)34 (35.1)55 (50.5) 
 Cardiovascular symptoms28 (6.9)6 (3.0)8 (8.2)14 (12.8) 
 Neurological symptoms11 (2.7)6 (3.0)2 (2.1)3 (2.8) 
 Gastrointestinal symptoms31 (7.6)15 (7.5)7 (7.2)9 (8.3) 
 Multiple symptoms28 (6.9)10 (5.0)7 (7.2)11 (10.1) 
Co-occurring with pyrexiaa91 (22.4)24 (12.0)13 (13.4)54 (49.5)< 0.001
Co-occurring with urticariaa207 (51.0)74 (37.0)57 (58.8)76 (69.7)< 0.001
Co-occurring with anaphylactic shocka15 (3.7)1 (0.5)5 (5.2)9 (8.3)0.002
With personal allergic historya,b152 (37.4)59 (29.5)39 (40.2)54 (49.5)0.002
  1. ED emergency department, POU pediatric observation unit
  2. aSignificant predictors
  3. bAsthma, allergic rhinitis