Use of sildenafil in an infant with persistent pulmonary hypertension secondary to lung and renal hypoplasia – a case report

Table 1 Serial targeted neonatal echocardiography findings of the indexed baby

Echocardiogram findings
Days of life	Day 2	Day 3	Day 5	Day 8	Day 48
RV dilatation	Moderate	Moderate	Mild	Mild	No
RV FAC (%)	29	57	42	52	58
TAPSE (cm)	0.7	0.7	0.85	0.9	N/A
PDA direction	Bidirectional L➔ R 70%	R➔L	Bidirectional L➔ R 70%	L➔R	closed
LV FS (%)	34	29	48	47	N/A^a
LVO (ml/kg/min)	70	74	151	255	287
Interventions (at the time of echo)
NO	–	+	+	–	–
PGE	–	–	+	–	–
Sildenafil	–	–	+	+	+

N/A Not available, RV Right ventricle, RVFAC Right ventricle fractional area change, TAPSE Tricuspid annular plane systolic excursion, PDA Patent ductus arteriosus, LV FS, Left ventricle fractional shortening, LVO Left ventricular output, NO Nitric oxide, PGE, Prostaglandin, LVEF Left ventricle ejection fraction, DOL Day of life
^aN/A: not available; quantitative measurement of LVEF was not performed due to movement artefacts, although LV contractility was unremarkable on eye balling

ISSN: 1471-2431