A clinical trial of enteral Levetiracetam for acute seizures in pediatric cerebral malaria

BMC Pediatrics

Table 2 Pharmacokinetic Parameters for Enteral Levetiracetam in Children with Cerebral Malaria (n = 7)

Parameter	Estimate	SE of Estimate	Median	BS 2.5th	BS 97.5th
V (L/kg)	0.711	0.06	0.696	0.562	0.825
CL (L/h/kg^0.75)	0.169	0.015	0.171	0.145	0.206
KA (hr⁻¹)	1.37	0.286	1.25	0.553	2.37
Lag time (h)	1.96	0.038	1.54	0.258	3.97
SCR factor	−1.37	0.343	− 1.34	−2.06	−0.631
Between Subject Variability
BSV-V	25%	5%	22%	5%	39%
BSV-CL	43%	6%	42%	28%	56%

V = volume of distribution; CL = total body clearance; KA = absorption rate constant; SCR = serum creatinine

ISSN: 1471-2431