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Table 2 Proportion of subjects affected by abnormal results in one or more of the three primary tests performed, overall and by age group

From: Burden of neurological and neurocognitive impairment in pediatric sickle cell anemia in Uganda (BRAIN SAFE): a cross-sectional study

 

Entire Cohort

Mean value

(N = 265)

Ages 1–4 years

Mean value

N = 113 (%)

Ages 5–12 years

Mean value

N = 152 (%)

Any of the 3 tests performed

57 (21.5%)

22 (23.7%)

43 (31.2%)

 Mean age for any abnormality (SD)

6.17 (3.3)

2.45 (0.74)

8.07 (2.32)

Prior stroke (N = 265)

15 (5.7%)

3 (3%)

12 (8.5%)

 Mean age for prior stroke (SD)

6.4 (2.56)

2.33 (0.58)

7.42 (1.62)

Elevated TCD (N = 251)

43 (17.1%)

17 (18.9%)

18 (13.6%)

 Abnormal TCD (N = 5)

5 (2.0%)

1 (1%)

3 (2%)

 Conditional TCD (N = 38)

38 (15.1%)

20 (20%)

18 (12.3%)

 Mean age for elevated TCD (SD)

4.92 (3.18)

2.38 (0.74)

7.48 (2.56)

Neurocognitive Dysfunction (N = 246)

27 (11.0%)

5 (5%)

22 (15.5%)

 Mean age for neurocognitive dysfunction (SD)

8.04 (3.12)

2.60 (0.89)

9.27 (1.80)

  1. One in five participants (57 of 265, 21.5%) had at least one abnormal result in the three tests performed. The most frequent findings were elevated TCD velocity and neurocognitive dysfunction