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Table 2 Serum adrenal steroid levels in both the NW and OW/OB groups at different pubertal stages

From: A cross-sectional survey of adrenal steroid hormones among overweight/obese boys according to puberty stage

 

Tanner stage

NW

 

OW/OB

 

P

N

Value

N

Value

Pregnenolone (ug/l)

Prepuberty

383

0.08(0.05–0.13)

141

0.08(0.05–0.12)

0.24

Early puberty

97

0.13(0.09–0.21)

93

0.09(0.05–0.14)

< 0.0001

Mid puberty

67

0.16(0.11–0.25)

31

0.12(0.06–0.21)

0.14

Late puberty

94

0.18(0.13–0.23)

36

0.19(0.11–0.29)

0.78

Post puberty

39

0.16(0.12–0.21)

18

0.20(0.11–0.29)

0.48

Corticosterone(ug/l)

Prepuberty

465

1.45 (0.87–2.92)

155

1.41(0.77–3.00)

0.59

Early puberty

116

1.36 (0.80–2.98)

100

1.62(0.88–3.38)

0.32

Mid puberty

70

1.38(0.63–2.54)

36

1.93(0.85–2.80)

0.21

Late puberty

101

1.31 (0.75–2.25)

44

1.07(0.72–2.80)

0.49

Post puberty

43

1.58 (0.74–2.93)

18

1.96(0.88–4.21)

0.30

17OH- progesterone (ng/ml)

Prepuberty

465

0.22 (0.15–0.38)

155

0.34(0.22–0.49)

< 0.0001

Early puberty

116

0.37 (0.26–0.51)

100

0.40(0.33–0.58)

0.05

Mid puberty

70

0.53 (0.36–0.75)

36

0.54(0.43–0.66)

0.59

Late puberty

101

0.65 (0.47–0.86)

44

0.51(0.39–0.84)

0.06

Post puberty

43

0.68 (0.49–0.94)

18

0.62(0.54–0.88)

0.47

DHEA (ug/l)

Prepuberty

465

0.70 (0.37–1.34)

155

1.49(0.88–2.31)

< 0.0001

Early puberty

116

2.12 (1.56–3.16)

100

2.31(1.66–3.30)

0.23

Mid puberty

70

3.10 (2.21–4.24)

36

3.34(2.26–5.07)

0.34

Late puberty

101

3.65 (2.64–4.59)

44

3.26(2.20–4.32)

0.41

Post puberty

43

4.36 (2.83–5.49)

18

3.57(2.54–5.55)

0.98

Androstenedione (ug/l)

Prepuberty

465

0.18 (0.13–0.25)

155

0.24(0.17–0.33)

< 0.0001

Early puberty

116

0.32 (0.23–0.44)

100

0.36(0.27–0.44)

0.37

Mid puberty

70

0.48 (0.34–0.65)

36

0.52(0.30–0.72)

0.86

Late puberty

101

0.63 (0.48–0.77)

44

0.53(0.40–0.68)

0.02

Post puberty

43

0.71 (0.57–0.90)

18

0.67(0.56–0.82)

0.85

FT (pg/ml)

Prepuberty

465

0.97 (0.59–1.36)

155

1.26(0.90–1.76)

< 0.0001

Early puberty

116

2.24 (1.69–3.49)

100

2.34(1.61–3.11)

0.68

Mid puberty

70

11.52 (5.66–23.35)

36

6.79 (3.52–19.18)

0.09

Late puberty

101

26.39 (17.12–37.36)

44

15.76 (8.52–26.07)

0.0006

Post puberty

43

34.16 (24.98–47.07)

18

24.47 (17.90–32.00)

0.02

SHBG (nmol/L)

Prepuberty

129

112.7 (87.8–150.2)

29

64.5 (41.6–117.1)

< 0.0001

Early puberty

42

79.54 (65.75–110.75)

31

45.1 (34–71.2)

< 0.0001

Mid puberty

24

43.25 (29.95–58.15)

11

35 (17–50.8)

0.12

  1. Values are presented as median and interquartile range (IQR)
  2. SHBG levels between the OW/OB and NW groups at the prepuberty, early puberty and mid puberty phases were compared. SHBG levels at the late puberty and post puberty phases between the OW/OB and NW groups were not compared due to the limited sample sizes
  3. NW normal weight, OW/OB overweight/obese, FT Free testosterone, DHEA Dehydroepiandrosterone, SHBG Sex hormone-binding globulin