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Table 3 Thyroid function test data of infants with initial and delayed thyroid-stimulating hormone elevations

From: Initial and delayed thyroid-stimulating hormone elevation in extremely low-birth-weight infants

   Initial TSH Elevation (N = 5) Delayed TSH Elevation (N = 42) P value
Initial TFT Age, HD 8.6 ± 1.1 (7–10) 7.3 ± 2.0 (5–14) 0.15
Corrected age 27.0 ± 1.6 (26+ 3–30+ 1) 26.0 ± 1.5 (24+ 5–29+ 2) 0.08
T4 (μg/dl) 2.4 ± 2.0 (0.2–8.4)
fT4 (ng/dl)a 0.7 ± 0.4 (0.1–1.1) 0.5 ± 0.0 (0.1–1.1)
TSH (μIU/ml) 61.0 ± 81.9 3.3 ± 4.0 < 0.001
36.7 (20.2–207.1)b 2.0 (0.4–17.4)b 0.001
Delayed TSH elevation Age, HD - 36.0 ± 25.2 (11–93) -
Corrected age - 30.1 ± 3.9 (25+ 3–38+ 1) -
T4 (μg/dl) 2.4 ± 1.4 (0.2–6.5)
fT4 (ng/dl) 0.7 ± 0.4 (0.02–1.6)
TSH (μIU/ml) 78.3 ± 138.4
35.3 (20.1–667.0)b
Peak TSH (μIU/ml) 88.1 ± 146.7
37.3 (20.4–667.0)b
  1. TSH Thyroid-stimulating hormone, TFT Thyroid function test, HD Hospital day, T4 Thyroxine, fT4 free thyroxine
  2. aThe number of subjects with delayed TSH elevation was insufficient for comparison
  3. bGeometric mean (range)