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Table 3 Thyroid function test data of infants with initial and delayed thyroid-stimulating hormone elevations

From: Initial and delayed thyroid-stimulating hormone elevation in extremely low-birth-weight infants

  

Initial TSH Elevation (N = 5)

Delayed TSH Elevation (N = 42)

P value

Initial TFT

Age, HD

8.6 ± 1.1 (7–10)

7.3 ± 2.0 (5–14)

0.15

Corrected age

27.0 ± 1.6 (26+ 3–30+ 1)

26.0 ± 1.5 (24+ 5–29+ 2)

0.08

T4 (ÎĽg/dl)

–

2.4 ± 2.0 (0.2–8.4)

–

fT4 (ng/dl)a

0.7 ± 0.4 (0.1–1.1)

0.5 ± 0.0 (0.1–1.1)

–

TSH (ÎĽIU/ml)

61.0 ± 81.9

3.3 ± 4.0

< 0.001

36.7 (20.2–207.1)b

2.0 (0.4–17.4)b

0.001

Delayed TSH elevation

Age, HD

-

36.0 ± 25.2 (11–93)

-

Corrected age

-

30.1 ± 3.9 (25+ 3–38+ 1)

-

T4 (ÎĽg/dl)

–

2.4 ± 1.4 (0.2–6.5)

–

fT4 (ng/dl)

–

0.7 ± 0.4 (0.02–1.6)

–

TSH (ÎĽIU/ml)

–

78.3 ± 138.4

–

35.3 (20.1–667.0)b

Peak TSH (ÎĽIU/ml)

–

88.1 ± 146.7

–

37.3 (20.4–667.0)b

  1. TSH Thyroid-stimulating hormone, TFT Thyroid function test, HD Hospital day, T4 Thyroxine, fT4 free thyroxine
  2. aThe number of subjects with delayed TSH elevation was insufficient for comparison
  3. bGeometric mean (range)