TY - JOUR AU - Black, R. E. AU - Cousens, S. AU - Johnson, H. L. AU - Lawn, J. E. AU - Rudan, I. AU - Bassani, D. G. PY - 2010 DA - 2010// TI - Child health epidemiology reference group of WHO and UNICEF. Global, regional, and national causes of child mortality in 2008: a systematic analysis JO - Lancet VL - 375 UR - https://doi.org/10.1016/S0140-6736(10)60549-1 DO - 10.1016/S0140-6736(10)60549-1 ID - Black2010 ER - TY - JOUR AU - Bryce, J. AU - Boschi-Pinto, C. AU - Shibuya, K. PY - 2005 DA - 2005// TI - WHO child health epidemiology reference group. WHO estimates of the causes of death in children JO - Lancet VL - 365 UR - https://doi.org/10.1016/S0140-6736(05)71877-8 DO - 10.1016/S0140-6736(05)71877-8 ID - Bryce2005 ER - TY - BOOK PY - 2008 DA - 2008// TI - Estimated Hib and pneumococcal deaths for children under 5 years of age ID - ref3 ER - TY - JOUR AU - O’Brien, K. L. AU - Wolfson, L. J. AU - Watt, J. P. AU - Henkle, E. AU - Deloria-Knoll, M. AU - McCall, N. PY - 2009 DA - 2009// TI - Hib and Pneumococcal Global Burden of Disease Study Team. Burden of disease caused by Streptococcus pneumoniae in children younger than 5 years: global estimates JO - Lancet VL - 374 UR - https://doi.org/10.1016/S0140-6736(09)61204-6 DO - 10.1016/S0140-6736(09)61204-6 ID - O’Brien2009 ER - TY - JOUR AU - Oliveira, L. H. AU - Camacho, L. A. AU - Coutinho, E. S. AU - Martinez-Silveira, M. S. AU - Carvalho, A. F. AU - Ruiz-Matus, C. PY - 2016 DA - 2016// TI - Impact and effectiveness of 10 and 13-valent pneumococcal conjugate vaccines on hospitalization and mortality in children aged less than 5 years in Latin American countries: a systematic review JO - PLoS One VL - 11 UR - https://doi.org/10.1371/journal.pone.0166736 DO - 10.1371/journal.pone.0166736 ID - Oliveira2016 ER - TY - JOUR AU - Moreira, M. AU - Castro, O. AU - Palmieri, M. AU - Efklidou, S. AU - Castagna, S. AU - Hoet, B. PY - 2016 DA - 2016// TI - A reflection on invasive pneumococcal disease and pneumococcal conjugate vaccination coverage in children in southern Europe (2009-2016) JO - Hum Vaccin Immunother VL - 20 ID - Moreira2016 ER - TY - JOUR AU - Chalmers, J. D. AU - Campling, J. AU - Dicker, A. AU - Woodhead, M. AU - Madhava, H. PY - 2016 DA - 2016// TI - A systematic review of the burden of vaccine preventable pneumococcal disease in UK adults JO - BMC Pulm Med VL - 16 UR - https://doi.org/10.1186/s12890-016-0242-0 DO - 10.1186/s12890-016-0242-0 ID - Chalmers2016 ER - TY - JOUR AU - Yao, K. H. AU - Yang, Y. H. PY - 2008 DA - 2008// TI - Streptococcus pneumoniae diseases in Chinese children: past, present and future JO - Vaccine VL - 26 UR - https://doi.org/10.1016/j.vaccine.2008.06.052 DO - 10.1016/j.vaccine.2008.06.052 ID - Yao2008 ER - TY - JOUR AU - Bao, Y. a. n. m. i. n. AU - Wang, Q. i. n. g. AU - Yao, K. a. i. h. u. AU - Xie, G. a. n. AU - Gao, W. e. i. AU - Huang, L. u. AU - Liu, X. i. a. o. l. i. AU - Zhu, C. h. u. n. q. i. n. AU - Chen, H. o. n. g. y. u. AU - Wang, H. e. p. i. n. g. AU - Shen, K. u. n. g. l. i. n. g. AU - Zheng, Y. u. e. j. i. e. AU - Yang, Y. o. n. g. h. o. n. g. PY - 2019 DA - 2019// TI - The changing phenotypes and genotypes of invasive pneumococcal isolates from children in Shenzhen during 2013–2017 JO - Vaccine VL - 37 UR - https://doi.org/10.1016/j.vaccine.2019.09.069 DO - 10.1016/j.vaccine.2019.09.069 ID - Bao2019 ER - TY - JOUR AU - Boulton, M. L. AU - Ravi, N. S. AU - Sun, X. AU - Huang, Z. AU - Wagner, A. L. PY - 2016 DA - 2016// TI - Trends in childhood pneumococcal vaccine coverage in Shanghai, China, 2005-2011: a retrospective cohort study JO - BMC Public Health VL - 16 UR - https://doi.org/10.1186/s12889-016-2785-7 DO - 10.1186/s12889-016-2785-7 ID - Boulton2016 ER - TY - JOUR AU - Hu, S. h. a. n. l. i. a. n. AU - Shi, Q. i. a. n. g. AU - Song, S. h. e. n. g. f. a. n. AU - Du, L. i. x. i. a. AU - He, J. i. a. n. g. j. i. a. n. g. AU - Chen, C. h. i. e. h. -. I. AU - Caldwell, R. o. n. a. l. d. AU - Wang, B. r. u. c. e. AU - Roberts, C. r. a. i. g. S. PY - 2014 DA - 2014// TI - Estimating the Cost-Effectiveness of the 7-Valent Pneumococcal Conjugate Vaccine in Shanghai, China JO - Value in Health Regional Issues VL - 3 UR - https://doi.org/10.1016/j.vhri.2014.04.007 DO - 10.1016/j.vhri.2014.04.007 ID - Hu2014 ER - TY - JOUR AU - Pan, F. AU - Han, L. AU - Huang, W. AU - Tang, J. AU - Xiao, S. AU - Wang, C. PY - 2015 DA - 2015// TI - Serotype distribution, antimicrobial susceptibility, and molecular epidemiology of Streptococcus pneumoniae isolated from children in Shanghai, China JO - PLoS One VL - 10 UR - https://doi.org/10.1371/journal.pone.0142892 DO - 10.1371/journal.pone.0142892 ID - Pan2015 ER - TY - STD TI - http://www.prismastatement.org/statement.htm. Available at August 12, 2019. UR - http://www.prismastatement.org/statement.htm ID - ref13 ER - TY - JOUR AU - Deng, X. AU - Arya, G. AU - Memari, N. AU - Mackenzie, R. AU - MacMullin, G. AU - Low, D. E. PY - 2015 DA - 2015// TI - Genetic analysis of invasive pneumococcal isolates from children in Ontario, Canada, 2007-2012 JO - Pediatr Infect Dis J VL - 34 UR - https://doi.org/10.1097/INF.0000000000000697 DO - 10.1097/INF.0000000000000697 ID - Deng2015 ER - TY - JOUR AU - DerSimonian, R. AU - Laird, N. PY - 1986 DA - 1986// TI - Meta-analysis in clinical trials JO - Control Clin Trials VL - 7 UR - https://doi.org/10.1016/0197-2456(86)90046-2 DO - 10.1016/0197-2456(86)90046-2 ID - DerSimonian1986 ER - TY - JOUR AU - Higgins, J. P. AU - Thompson, S. G. PY - 2002 DA - 2002// TI - Quantifying heterogeneity in a meta-analysis JO - Stat Med VL - 21 UR - https://doi.org/10.1002/sim.1186 DO - 10.1002/sim.1186 ID - Higgins2002 ER - TY - JOUR AU - Higgins, J. P. T. PY - 2003 DA - 2003// TI - Measuring inconsistency in meta-analyses JO - BMJ VL - 327 UR - https://doi.org/10.1136/bmj.327.7414.557 DO - 10.1136/bmj.327.7414.557 ID - Higgins2003 ER - TY - JOUR AU - Egger, M. AU - Davey Smith, G. AU - Schneider, M. AU - Minder, C. PY - 1997 DA - 1997// TI - Bias in meta-analysis detected by a simple, graphical test JO - BMJ VL - 315 UR - https://doi.org/10.1136/bmj.315.7109.629 DO - 10.1136/bmj.315.7109.629 ID - Egger1997 ER - TY - JOUR AU - Xue, L. AU - Yao, K. AU - Xie, G. AU - Zheng, Y. AU - Wang, C. AU - Shang, Y. PY - 2010 DA - 2010// TI - Serotype distribution and antimicrobial resistance of Streptococcus pneumoniae isolates that cause invasive disease among Chinese children JO - Clin Infect Dis VL - 50 UR - https://doi.org/10.1086/650534 DO - 10.1086/650534 ID - Xue2010 ER - TY - JOUR AU - Ma, X. AU - Zhao, R. AU - Ma, Z. AU - Yao, K. AU - Yu, S. AU - Zheng, Y. PY - 2013 DA - 2013// TI - Serotype distribution and antimicrobial resistance of Streptococcus pneumoniae isolates causing invasive diseases from Shenzhen Children’s hospital JO - PLoS One VL - 8 UR - https://doi.org/10.1371/journal.pone.0067507 DO - 10.1371/journal.pone.0067507 ID - Ma2013 ER - TY - JOUR AU - Liu, C. AU - Xiong, X. AU - Xu, W. AU - Sun, J. AU - Wang, L. AU - Li, J. PY - 2013 DA - 2013// TI - Serotypes and patterns of antibiotic resistance in strains causing invasive pneumococcal disease in children less than 5 years of age JO - PLoS One VL - 8 UR - https://doi.org/10.1371/journal.pone.0054254 DO - 10.1371/journal.pone.0054254 ID - Liu2013 ER - TY - JOUR AU - Ding, Y. AU - Geng, Q. AU - Tao, Y. AU - Lin, Y. AU - Wang, Y. AU - Black, S. PY - 2015 DA - 2015// TI - Etiology and epidemiology of children with acute otitis media and spontaneous otorrhea in Suzhou, China JO - Pediatr Infect Dis J VL - 34 UR - https://doi.org/10.1097/INF.0000000000000617 DO - 10.1097/INF.0000000000000617 ID - Ding2015 ER - TY - JOUR AU - Kang, L. H. AU - Liu, M. J. AU - Xu, W. C. AU - Cui, J. J. AU - Zhang, X. M. AU - Wu, K. F. PY - 2016 DA - 2016// TI - Molecular epidemiology of pneumococcal isolates from children in China JO - Saudi Med J VL - 37 UR - https://doi.org/10.15537/smj.2016.4.14507 DO - 10.15537/smj.2016.4.14507 ID - Kang2016 ER - TY - JOUR AU - Liu, C. L. AU - Zhao, C. J. AU - Liu, Y. D. AU - Wang, H. PY - 2010 DA - 2010// TI - Study of serotype distribution, antimicrobial resistance patterns and molecular epidemiology in 148 isolates of invasive Streptococcus pneumoniae JO - Natl Med J China VL - 90 ID - Liu2010 ER - TY - JOUR AU - Xu, F. AU - Chi, F. L. AU - Tan, H. AU - Liu, X. M. AU - Cao, T. AU - Pan, W. PY - 2012 DA - 2012// TI - Study on serotype distribution in 48 isolates of invasive Streptococcus pneumoniae with which children infected JO - Chin J Biochem Pharm VL - 33 ID - Xu2012 ER - TY - JOUR AU - Lu, C. PY - 2015 DA - 2015// TI - Serotype distribution in invasive Streptococcus pneumoniae from hospitalized pediatric patients JO - Int J Lab Med VL - 36 ID - Lu2015 ER - TY - JOUR AU - Zhou, K. AU - Xie, G. J. AU - Wang, X. W. AU - Xu, F. AU - Yao, K. H. PY - 2015 DA - 2015// TI - Clinical characteristic of invasive pneumococcal disease and its serotype distribution JO - Chin J Nosocomiol VL - 25 ID - Zhou2015 ER - TY - JOUR AU - Song, X. Q. AU - Duan, D. R. AU - Lai, J. X. PY - 2015 DA - 2015// TI - Serotype and drug resistance of Streptococcus pneumoniae from preschool children with suppurative otitis media JO - Chin J Microecol VL - 27 ID - Song2015 ER - TY - JOUR AU - Wang, Y. T. AU - Guo, Y. H. AU - Wang, Q. AU - Jia, Z. Y. AU - Zhang, W. C. AU - Sun, Y. Q. PY - 2016 DA - 2016// TI - Serotype analysis of 43 strains of invasive Streptococcus pneumoniae isolated in Hebei Province, 2014 JO - Chin J Vaccines Immun VL - 22 ID - Wang2016 ER - TY - JOUR AU - Lyu, S. AU - Yao, K. H. AU - Dong, F. AU - Xu, B. P. AU - Liu, G. AU - Wang, Q. PY - 2016 DA - 2016// TI - Vaccine serotypes of Streptococcus pneumoniae with high-level antibiotic resistance isolated more frequently seven years after the licensure of PCV7 in Beijing JO - Pediatr Infect Dis J VL - 35 UR - https://doi.org/10.1097/INF.0000000000001000 DO - 10.1097/INF.0000000000001000 ID - Lyu2016 ER - TY - JOUR AU - Liu, Y. AU - Wang, H. AU - Chen, M. AU - Sun, Z. AU - Zhao, R. AU - Zhang, L. PY - 2008 DA - 2008// TI - Serotype distribution and antimicrobial resistance patterns of Streptococcus pneumoniae isolated from children in China younger than 5 years JO - Diagn Microbiol Infect Dis VL - 61 UR - https://doi.org/10.1016/j.diagmicrobio.2008.02.004 DO - 10.1016/j.diagmicrobio.2008.02.004 ID - Liu2008 ER - TY - JOUR AU - Dong, F. AU - Zhen, J. H. AU - Wang, Y. AU - Xu, B. P. AU - Wang, Q. AU - Liu, G. PY - 2016 DA - 2016// TI - Analysis of features of streptococcus pneumoniae isolated from the cultured bacteria sample in pediatric patients JO - Chin J Pract Pediatr VL - 31 ID - Dong2016 ER - TY - JOUR AU - Li, J. AU - Ma, L. J. AU - Shi, W. AU - Zhou, L. AU - Xu, W. J. AU - Yao, K. H. PY - 2015 DA - 2015// TI - Serotype distribution and antimicrobial susceptibility of Streptococcus pneumoniae isolated in hospitalized children JO - Chin J Lab Med VL - 38 ID - Li2015 ER - TY - JOUR AU - Miao, D. Q. AU - Xu, F. AU - Li, J. Q. AU - Liu, J. J. AU - Shao, Z. Q. AU - Zhu, T. PY - 2016 DA - 2016// TI - Serotype distribution of streptococcus pneumoniae from children's clinical isolates in Nanjing JO - China Med Eng VL - 24 ID - Miao2016 ER - TY - JOUR AU - Chen, Y. AU - Deng, W. AU - Wang, S. M. AU - Mo, Q. M. AU - Jia, H. AU - Wang, Q. PY - 2011 DA - 2011// TI - Burden of pneumonia and meningi-tis caused by Streptococcus pneumoniae in China among children under 5 years of age: a systematic literature review JO - PLoS One VL - 6 UR - https://doi.org/10.1371/journal.pone.0027333 DO - 10.1371/journal.pone.0027333 ID - Chen2011 ER - TY - JOUR AU - Johnson, H. L. AU - Deloria-Knoll, M. AU - Levine, O. S. AU - Stoszek, S. K. AU - Freimanis Hance, L. AU - Reithinger, R. PY - 2010 DA - 2010// TI - Systematic evaluation of serotypes causing invasive pneumococcal disease among children under five: the pneumococcal global serotype project JO - PLoS Med VL - 7 UR - https://doi.org/10.1371/journal.pmed.1000348 DO - 10.1371/journal.pmed.1000348 ID - Johnson2010 ER - TY - JOUR AU - Kim, S. H. AU - Song, J. H. AU - Chung, D. R. AU - Thamlikitkul, V. AU - Yang, Y. AU - Wang, H. PY - 2012 DA - 2012// TI - Changing trends in antimicrobial resistance and serotypes of Streptococcus pneumoniae isolates in Asian countries: an Asian network for surveillance of resistant pathogens (ANSORP) study JO - Antimicrob Agents Chemother VL - 56 UR - https://doi.org/10.1128/AAC.05658-11 DO - 10.1128/AAC.05658-11 ID - Kim2012 ER - TY - JOUR AU - Plessis, M. AU - Allam, M. AU - Tempia, S. AU - Wolter, N. AU - Gouveia, L. AU - Mollendorf, C. AU - Jolley, K. A. AU - Mbelle, N. AU - Wadula, J. AU - Cornick, J. E. AU - Everett, D. B. AU - McGee, L. AU - Breiman, R. F. AU - Gladstone, R. A. AU - Bentley, S. D. AU - Klugman, K. P. AU - Gottberg, A. PY - 2016 DA - 2016// TI - Phylogenetic analysis of invasive serotype 1 pneumococcus in South Africa, 1989 to 2013 JO - J Clin Microbiol VL - 54 UR - https://doi.org/10.1128/JCM.00055-16 DO - 10.1128/JCM.00055-16 ID - Plessis2016 ER - TY - JOUR AU - Brueggemann, A. B. AU - Peto, T. E. AU - Crook, D. W. AU - Butler, J. C. AU - Kristinsson, K. G. AU - Spratt, B. G. PY - 2004 DA - 2004// TI - Temporal and geographic stability of the serogroup-specific invasive disease potential of Streptococcus pneumoniae in children JO - J Infect Dis VL - 190 UR - https://doi.org/10.1086/423820 DO - 10.1086/423820 ID - Brueggemann2004 ER - TY - JOUR AU - Wang, L. AU - Fu, J. AU - Liang, Z. AU - Chen, J. PY - 2017 DA - 2017// TI - Prevalence and serotype distribution of nasopharyngeal carriage of Streptococcus pneumoniae in China: a meta-analysis JO - BMC Infect Dis VL - 17 UR - https://doi.org/10.1186/s12879-017-2816-8 DO - 10.1186/s12879-017-2816-8 ID - Wang2017 ER - TY - JOUR AU - Feikin, D. R. AU - Kagucia, E. W. AU - Loo, J. D. AU - Link-Gelles, R. AU - Puhan, M. A. AU - Cherian, T. PY - 2013 DA - 2013// TI - Serotype Replacement Study Group. Serotype-specific changes in invasive pneumococcal disease after pneumococcal conjugate vaccine introduction: a pooled analysis of multiple surveillance sites JO - PLoS Med VL - 10 UR - https://doi.org/10.1371/journal.pmed.1001517 DO - 10.1371/journal.pmed.1001517 ID - Feikin2013 ER - TY - JOUR AU - Yu, H. AU - Yang, W. AU - Varma, J. K. PY - 2012 DA - 2012// TI - To save children’s lives, China should adopt an initiative to speed introduction of pneumonia vaccines JO - Health Aff VL - 31 UR - https://doi.org/10.1377/hlthaff.2011.1272 DO - 10.1377/hlthaff.2011.1272 ID - Yu2012 ER - TY - JOUR AU - Guevara, M. AU - Barricarte, A. AU - Torroba, L. AU - Herranz, M. AU - Gil-Setas, A. AU - Gil, F. PY - 2016 DA - 2016// TI - Working Group for Surveillance of the Pneumococcal Invasive Disease in Navarra. Direct, indirect and total effects of 13-valent pneumococcal conjugate vaccination on invasive pneumococcal disease in children in Navarra, Spain, 2001 to 2014: cohort and case-control study JO - Euro Surveill VL - 21 UR - https://doi.org/10.2807/1560-7917.ES.2016.21.14.30186 DO - 10.2807/1560-7917.ES.2016.21.14.30186 ID - Guevara2016 ER - TY - JOUR AU - Zheng, J. AU - Cao, L. AU - Guo, S. AU - Wang, L. A. K. AU - Yu, W. PY - 2012 DA - 2012// TI - Survey of the current situation of category 2 vaccines in Chinese children aged 1 to 2 years JO - Chin J Vaccine Immun VL - 18 ID - Zheng2012 ER - TY - JOUR AU - Mo, X. AU - Gai Tobe, R. AU - Liu, X. AU - Mori, R. PY - 2016 DA - 2016// TI - Cost-effectiveness and health benefits of pediatric 23-valent pneumococcal polysaccharide vaccine, 7-valent pneumococcal conjugate vaccine and forecasting 13-valent pneumococcal conjugate vaccine in China JO - Pediatr Infect Dis J VL - 35 UR - https://doi.org/10.1097/INF.0000000000001288 DO - 10.1097/INF.0000000000001288 ID - Mo2016 ER - TY - JOUR AU - Hu, S. AU - Shi, Q. AU - Chen, C. I. AU - Caldwell, R. AU - Wang, B. AU - Du, L. PY - 2014 DA - 2014// TI - Estimated public health impact of nationwide vaccination of infants with 7-valent pneumococcal conjugate vaccine (PCV7) in China JO - Int J Infect Dis VL - 26 UR - https://doi.org/10.1016/j.ijid.2014.04.012 DO - 10.1016/j.ijid.2014.04.012 ID - Hu2014 ER - TY - JOUR AU - Zhao, C. AU - Zhang, F. AU - Chu, Y. AU - Liu, Y. AU - Cao, B. AU - Chen, M. PY - 2013 DA - 2013// TI - Phenotypic and genotypic characteristic of invasive pneumococcal isolates from both children and adult patients from a multicenter surveillance in China 2005-2011 JO - PLoS One VL - 8 UR - https://doi.org/10.1371/journal.pone.0082361 DO - 10.1371/journal.pone.0082361 ID - Zhao2013 ER - TY - JOUR AU - Bowers, J. R. AU - Driebe, E. M. AU - Nibecker, J. L. AU - Wojack, B. R. AU - Sarovich, D. S. AU - Wong, A. H. PY - 2012 DA - 2012// TI - Dominance of multidrug resistant CC271 clones in macrolide-resistant streptococcus pneumoniae in Arizona JO - BMC Microbiol VL - 12 UR - https://doi.org/10.1186/1471-2180-12-12 DO - 10.1186/1471-2180-12-12 ID - Bowers2012 ER - TY - JOUR AU - Messina, A. F. AU - Katz-Gaynor, K. AU - Barton, T. AU - Ahmad, N. AU - Ghaffar, F. AU - Rasko, D. PY - 2007 DA - 2007// TI - Impact of the pneumococcal conjugate vaccine on serotype distribution and antimicrobial resistance of invasive Streptococcus pneumoniae isolates in Dallas, TX, children from 1999 through 2005 JO - Pediatr Infect Dis J VL - 26 UR - https://doi.org/10.1097/INF.0b013e31805cdbeb DO - 10.1097/INF.0b013e31805cdbeb ID - Messina2007 ER - TY - JOUR AU - Imai, S. AU - Ito, Y. AU - Ishida, T. AU - Hirai, T. AU - Ito, I. AU - Maekawa, K. PY - 2009 DA - 2009// TI - Kansai community acquired pneumococcal pneumonia study group. High prevalence of multidrug-resistant pneumococcal molecular epidemiology network clones among Streptococcus pneumoniae isolates from adult patients with community-acquired pneumonia in Japan JO - Clin Microbiol Infect VL - 15 UR - https://doi.org/10.1111/j.1469-0691.2009.02935.x DO - 10.1111/j.1469-0691.2009.02935.x ID - Imai2009 ER - TY - JOUR AU - Eun, B. W. AU - Kim, S. J. AU - Cho, E. Y. AU - Lee, J. AU - Choi, E. H. AU - Lee, H. J. PY - 2010 DA - 2010// TI - Genetic structure of Streptococcus pneumoniae isolated from children in a tertiary care university hospital, in Korea, 1995 to 2005 JO - Diagn Microbiol Infect Dis VL - 68 UR - https://doi.org/10.1016/j.diagmicrobio.2010.07.008 DO - 10.1016/j.diagmicrobio.2010.07.008 ID - Eun2010 ER - TY - JOUR AU - Qian, J. AU - Yao, K. AU - Xue, L. AU - Xie, G. AU - Zheng, Y. AU - Wang, C. PY - 2012 DA - 2012// TI - Diversity of pneumococcal surface protein A (PspA) and relation to sequence typing in Streptococcus pneumoniae causing invasive disease in Chinese children JO - Eur J Clin Microbiol Infect Dis VL - 31 UR - https://doi.org/10.1007/s10096-011-1296-9 DO - 10.1007/s10096-011-1296-9 ID - Qian2012 ER - TY - JOUR AU - He, M. AU - Yao, K. AU - Shi, W. AU - Gao, W. AU - Yuan, L. AU - Yu, S. PY - 2015 DA - 2015// TI - Dynamics of serotype 14 Streptococcus pneumoniae population causing acute respiratory infections among children in China (1997-2012) JO - BMC Infect Dis VL - 15 UR - https://doi.org/10.1186/s12879-015-1008-7 DO - 10.1186/s12879-015-1008-7 ID - He2015 ER -