Table 4 Prenatal exposures and pubertal timing, measured by HD:SDSa, when further adjusting for childhood BMI at 7 years in children born 2000–2003, the Danish National Birth Cohort, Denmark
Model 1b: Adjusted difference in HD:SDS when restricting to information on childhood BMI | Model 2c: Adjusted difference in HD:SDS when also adjusting for childhood BMI | |||
|---|---|---|---|---|
Prenatal exposures | Difference | 95% CI | Difference | 95% CI |
Boys (n = 13,674) | ||||
Pre-pregnancy BMI | ||||
< 18.5 kg/m2 | −0.17 | −0.26, − 0.08 | − 0.12 | − 0.20, − 0.03 |
18.5–24.9 kg/m2 | Ref | Ref | ||
25.0–29.9 kg/m2 | 0.12 | 0.07, 0.16 | 0.06 | 0.01, 0.10 |
30.0+ kg/m2 | 0.24 | 0.18, 0.31 | 0.13 | 0.06, 0.19 |
Trend analysis (kg/m2) | 0.023 | 0.018, 0.027 | 0.012 | 0.007, 0.016 |
Smoking in pregnancy | ||||
Non-smoker | Ref | Ref | ||
Stopped smoking | 0.00 | −0.05, 0.06 | −0.02 | −0.07, 0.04 |
1–9 daily cigarettes | −0.01 | −0.07, 0.06 | −0.05 | −0.12, 0.01 |
10–14 daily cigarettes | 0.01 | −0.09, 0.11 | −0.04 | −0.13, 0.06 |
15+ daily cigarettes | 0.01 | −0.13, 0.14 | −0.05 | −0.18, 0.08 |
Trend analysis (group) | 0.001 | −0.018, 0.021 | −0.016 | −0.036, 0.003 |
Alcohol in pregnancy | ||||
Abstainers | Ref | Ref | ||
< 1 units weekly | 0.00 | −0.04, 0.04 | 0.00 | −0.04, 0.04 |
1–3 units weekly | 0.00 | −0.06, 0.05 | 0.00 | −0.05, 0.05 |
> 3 units weekly | −0.12 | −0.23, − 0.01 | − 0.11 | − 0.22, 0.00 |
Trend analysis (units) | −0.018 | −0.035, − 0.002 | − 0.017 | − 0.033, 0.000 |
Girls (n = 11,550) | ||||
Pre-pregnancy BMI | ||||
< 18.5 kg/m2 | −0.02 | −0.11, 0.07 | 0.05 | −0.04, 0.14 |
18.5–24.9 kg/m2 | Ref | Ref | ||
25.0–29.9 kg/m2 | 0.10 | 0.06, 0.15 | 0.04 | −0.01, 0.08 |
30.0+ kg/m2 | 0.16 | 0.09, 0.24 | 0.05 | −0.02, 0.11 |
Trend analysis (kg/m2) | 0.018 | 0.014, 0.023 | 0.007 | 0.002, 0.011 |
Smoking in pregnancy | ||||
Non-smoker | Ref | Ref | ||
Stopped smoking | −0.05 | −0.11, 0.00 | −0.08 | −0.14, − 0.02 |
1–9 daily cigarettes | 0.03 | −0.04, 0.10 | −0.03 | −0.09, 0.04 |
10–14 daily cigarettes | 0.05 | −0.06, 0.15 | 0.00 | −0.10, 0.10 |
15+ daily cigarettes | 0.04 | −0.10, 0.19 | −0.02 | −0.16, 0.12 |
Trend analysis (group) | 0.009 | −0.012, 0.029 | −0.012 | −0.032, 0.008 |
Alcohol in pregnancy | ||||
Abstainers | Ref | |||
< 1 units weekly | −0.03 | −0.07, 0.01 | −0.03 | −0.07, 0.01 |
1–3 units weekly | −0.06 | −0.11, 0.00 | −0.06 | −0.12, − 0.01 |
> 3 units weekly | 0.02 | −0.11, 0.14 | 0.00 | −0.12, 0.12 |
Trend analysis (units) | −0.012 | −0.029, 0.006 | −0.014 | −0.031, 0.003 |