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Table 4 An evaluation of the impact of the age of MMR vaccine administration on the effectiveness of the vaccine to prevent cases of measles

From: Childhood MMR vaccination and the incidence rate of measles infection: a ten year longitudinal cohort study of American children born in the 1990s

Model

Variable

Hazard Ratio

(95% CI)

VE

(95% CI)

p-value

χ2

I

Vaccinateda vs Unvaccinatedb

(≥ 12 months-old)

0.147

(0.071 to 0.305)

85.3%

(69.5 to 92.9%)

<  0.0001

26.5

Vaccinated vs Unvaccinated

(≥ 16 months-old)

0.100

(0.036 to 0.273)

90%

(72.7 to 86.4%)

<  0.0001

20.2

Vaccinated vs Unvaccinated

(≥ 20 months-old)

0.061

(0.015 to 0.247)

93.9%

(75.3 to 98.5%)

<  0.0001

15.3

II

Vaccinated vs Unvaccinated

(≥ 12 months-old)

0.173

(0.083 to 0.360)

82.7%

(64 to 91.7%)

<  0.0001

22.1

Gender (Female vs Male)

1.032

(0.673 to 1.584)

 

0.89

0.02

County of Residence

0.994

(0.983 to 1.005)

 

0.27

1.20

Date of Birth

0.999

(0.999 to 0.999)

 

<  0.0001

30

Vaccinated vs Unvaccinated

(≥ 16 months-old)

0.111

(0.040 to 0.303)

88.9%

(69.7 to 96%)

<  0.0001

18.4

Gender (Female vs Male)

1.109

(0.718 to 1.715)

 

0.64

0.22

County of Residence

0.995

(0.984 to 1.007)

 

0.42

0.66

Date of Birth

0.999

(0.999 to 0.999)

 

<  0.0001

28.1

Vaccinated vs Unvaccinated

(≥ 20 months-old)

0.070

(0.017 to 0.287)

93%

(71.3 to 98.3%)

<  0.0001

13.7

Gender (Female vs Male)

1.027

(0.658 to 1.602)

 

0.91

0.01

County of Residence

0.996

(0.985 to 1.008)

 

0.49

0.47

Date of Birth

0.999

(0.999 to 1.000)

 

<  0.0001

27.4

  1. Italicized results are statistically significant. Model I = unadjusted, Model II = adjusted for gender, county of residence, and date of birth
  2. CI Confidence interval, VE Vaccine effectiveness
  3. a Persons received only 1 dose of MMR vaccine
  4. b Persons received no doses of measles-containing vaccine