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Table 3 Cox proportional hazards model results examining the relationship between MMR vaccination and diagnosed measles

From: Childhood MMR vaccination and the incidence rate of measles infection: a ten year longitudinal cohort study of American children born in the 1990s

Model

Variable

Hazard Ratio

(95% CI)

VE

(95% CI)

p-value

χ2

I

Vaccinateda vs Unvaccinatedb (all ages)

0.164

(0.082 to 0.328)

83.6%

(67.2 to 91.8%)

<  0.0001

26.2

Vaccinated vs Unvaccinated

(≥ 12 months-old) c

0.291

(0.136 to 0.622)

70.9%

(37.8 to 86.4%)

0.0015

10.1

II

Vaccinated vs Unvaccinated (all ages)

0.193

(0.096 to 0.385)

80.7%

(61.5% to 90.4)

<  0.0001

21.7

Gender (Female vs Male)

1.01

(0.659 to 1.544)

 

0.97

0.002

County of Residence

0.993

(0.982 to 1.004)

 

0.24

1.40

Date of Birth

0.999

(0.999 to 0.999)

 

<  0.0001

30.2

Vaccinated vs Unvaccinated

(≥ 12 months-old) c

0.346

(0.161 to 0.744)

65.4%

(25.6 to 83.9%)

0.00065

7.39

Gender (Female vs Male)

0.959

(0.544 to 1.692)

 

0.89

0.02

County of Residence

0.997

(0.982 to 1.011)

 

0.65

0.21

Date of Birth

0.999

(0.999 to 0.999)

 

<  0.0001

18.8

  1. Italicized results are statistically significant. Model I = unadjusted, Model II = adjusted for gender, county of residence, and date of birth
  2. CI Confidence interval, VE Vaccine effectiveness
  3. aPersons received only 1 dose of MMR vaccine
  4. bPersons received no doses of measles-containing vaccine
  5. cOnly persons diagnosed with measles at ≥12 months-old were included in the unvaccinated cohort and only examining persons receiving MMR vaccine at ≥12 months-old in the vaccinated cohort, so as to ensure direct overlap in ages with the vaccinated and unvaccinated cohorts
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BMC Pediatrics

ISSN: 1471-2431

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