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Table 4 Carbapenem resistant Enterobacteriaceae determinants and susceptibility profiles

From: A review of -multidrug-resistant Enterobacteriaceae in a neonatal unit in Johannesburg, South Africa

Number Organism Carbapenemase Gene Antibiotic Susceptibility
Amikacin Ciprofloxacin Ertapenem Meropenem Imipenem
1. K. pneumoniae *NT **R ***S R R S
2. K. pneumoniae NT ****I S R I S
3. K. pneumoniae NDM R S NT R R
4. K. pneumoniae NDM R R R R R
5. K. pneumoniae NDM S S NT R R
6. K. pneumoniae NDM R S R R R
7. K. pneumoniae VIM S S S R R
8. K. pneumoniae NT S S R R R
9. K. pneumoniae NT S S R R R
10. K. pneumoniae NDM S S NT R R
11. K. pneumoniae NDM S S R R R
12. K. pneumoniae NDM R S NT R R
13. K. pneumoniae NDM R S NT R R
14. K. pneumoniae NDM S S NT R R
15. K. pneumoniae NDM S S R R R
16. K. pneumoniae NDM R S NT R R
17. K. pneumoniae NDM R S R R R
18. K. pneumoniae NDM S S NT R R
19. K. pneumoniae NDM S S NT R R
20. K. pneumoniae NT S S R R R
21. K. pneumoniae NEG S S R R R
22. K. pneumoniae NT S R R S I
23. K. oxytoca VIM S S NT R R
24. E. cloacae NT S S S S R
25. E. cloacae NT S S R S S
26. C. freundii NDM R S R R R
  1. NT- not tested
  2. **R- resistant
  3. ***S- susceptible
  4. ****I- intermediately-susceptible
  5. The susceptibility to Amikacin and/or Ciprofloxacin allows these antibiotics to be considered as treatment options either as (1) monotherapy or (2) in combination with each other or (3) in combination with a carbapenem, which spares colistin use
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