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Table 2 Patient study timeline

From: Early prediction of spontaneous Patent Ductus Arteriosus (PDA) closure and PDA-associated outcomes: a prospective cohort investigation

  Study Period
<72 h Week 1 Week 2 Week 3 Week 4 Bi-weekly 36-weeks PMA Every 2-3 months f 22 to 26-months CA
 Eligibility screen (Echocardiogram) X         
 Informed consent X         
Data collection
 Biomarkers   X X X X     
 Echocardiography a   X X X X X d    
 Respiratory support        X   
 Echocardiography a        X e X X
 Bayley III b          X
Catheter-based PDA Closure c          X
  1. a traditional, myocardial deformation imaging, tissue Doppler imaging
  2. b Bayley Scales of Infant and Toddler Development, 3rd Edition (Gross Motor Development Scaled Standard Score postnatal age, Fine Motor Development Scaled Standard Score postnatal age, Cognitive Composite Score, Language Composite Score)
  3. c patients with persistent PDA at 22 to 26-months corrected age (CA)
  4. d obtained bi-weekly until 36-weeks postmenstrual age (PMA) if PDA remains open
  5. e All infants receive echocardiogram at 36 weeks irrespective of previous PDA status
  6. f until documented ductal closure per local standard of care
  7. Note: If PDA closed, additional weekly echocardiograms not obtained