From: The analysis of endocrine disruptors in patients with central precocious puberty
Author (year), country | Subjects | Phthalates or BPA | Results |
---|---|---|---|
Colon et al. [14] (2000) Puerto Rico | 41 thelarche patients, 35 controls | DBP, BBP, DEP MEHP | Elevated serum phthalates in premature thelarche |
Chou et al. [15] (2009) Taiwan | 26 CPP, 30 premature thelarche 33 controls | MMP, MBuP MBzP, MEHP | Urinary levels of MMP were higher in premature thelarche (but not in CPP group) None of the phthalates showed association with true gonadotropin-dependent puberty |
Lomenick et al. [16] (2010) USA | 28 CPP girls, 28 age-matched controls | MBP, MBzP MCPP, MECPP MEHHP, MEHP MEOHP, MEP MiBP | Phthalate exposure is not associated with precocious puberty in female children. |
Chen et al. [17] (2013) Taiwan | 73 CPP girls, 31 controls | MMP, MEP MBP, MBzP MEHP, MEHHP MEOHP | All seven urinary phthalate metabolite levels in the CPP group were significantly higher (P < 0.05) than in prepubescent controls. |
Srilanchakon et al. [18] (2007) Thailand | 42 precocious puberty, 17 early puberty, 77 age-matched controls | MMP MEP | Urinary MEP concentration was higher in girls with precocious puberty than in controls |
Durmaz et al. [19] (2014) Turkey | 28 CPP non-obese girls, 25 controls | BPA | Urinary BPA levels in CPP group were higher compared to the control |
Özgen et al. [20] (2016) Turkey | 28 CPP, 28 premature thelarche, 22 prepubertal controls | BPA | Urinary BPA levels did not differentiate between groups |
Chen et al. [21] (2018) China | 136 CPP, 136 age-, BMI-matched controls | BPA | BPA exposure was associated with increased incidence of CPP |