Comparison between clinical features and prognosis of malignancy- and non-malignancy–associated pediatric hemophagocytic lymphohistiocytosis

Table 3 Results of multivariate analysis of prognostic factors of malignancy-associated hemophagocytic lymphohistiocytosis (HLH)

Variable	HR	95% CI	p value
Group	1.893	0.698–5.134	0.210
Age	1.069	0.939–1.219	0.313
Sex	0.855	0.351–2.082	0.730
EBV-positive	0.861	0.375–1.980	0.725
@Ne	0.963	0.789–1.175	0.708
HGB (< 60 g/L)	0.973	0.950–0.997	0.027
Fibrinogen	1.242	0.808–1.910	0.322
Ferritin	1.000	1.000–1.000	0.235
LDH	1.000	1.000–1.000	0.714
DIC	1.745	0.700–4.353	0.232
Jaundice	1.911	0.715–5.105	0.197
Bone marrow involvement	0.374	0.151–0.928	0.034
TG	0.897	0.725–1.110	0.316
PLT (< 30 × 10⁹/L)	1.000	0.992–1.007	0.917
Albumin (< 25 g/L)	0.875	0.783–0.976	0.017
ALT	1.000	0.999–1.001	0.615
AST	1.000	1.000–1.001	0.491
Splenomegaly	0.641	0.238–1.727	0.379
Cholecystitis	1.329	0.381–4.641	0.655
Pleural effusion	0.520	0.189–1.431	0.205
Pneumonia	1.135	0.521–2.476	0.750

HR Hazard ratio, 95% CI 95% confidence interval, EBV Epstein–Barr virus, HGB Hemoglobin, LDH Lactate dehydrogenase, DIC Disseminated intravascular coagulation, TG Triglycerides, PLT Platelets, ALT Alanine aminotransferase, AST Aspartate aminotransferase, @Ne Neutrophils granulocyte

ISSN: 1471-2431