Comparison between clinical features and prognosis of malignancy- and non-malignancy–associated pediatric hemophagocytic lymphohistiocytosis

Table 2 Results of univariate analysis of prognostic factors of malignancy-associated hemophagocytic lymphohistiocytosis (HLH)

Variable	HR	95% CI	p value	Q value
Age	0.966	0.873–1.069	0.506	0.843
Gender	0.815	0.418–1.587	0.547	0.841
EBV-positive	0.864	0.437–1.708	0.674	0.963
@Ne	0.949	0.823–1.095	0.476	0.865
HGB (< 60 g/L)	0.968	0.949–0.987	0.001	0.01
Fibrinogen	1.043	0.744–1.462	0.807	1.009
Ferritin	1.000	1.000–1.000	0.878	1.033
LDH	1.000	1.000–1.000	0.469	0.938
DIC	3.045	1.571–5.901	0.001	0.007
Jaundice	1.614	0.838–3.109	0.153	0.612
Bone marrow involvement	0.722	0.375–1.390	0.330	0.733
TG	0.890	0.718–1.103	0.288	0.823
PLT (< 30 × 10⁹/L)	0.993	0.985–1.000	0.042	0.210
Albumin (< 25 g/L)	0.883	0.827–0.943	0.000	0.000
ALT	1.000	1.000–1.000	0.951	1.001
AST	1.000	1.000–1.000	0.213	0.710
Splenomegaly	1.038	0.487–2.210	0.923	1.026
Cholecystitis	1.022	0.360–2.896	0.968	0.968
Pleural effusion	0.876	0.431–1.781	0.714	0.952
Pneumonia	1.389	0.721–2.676	0.325	0.813

HR Hazard ratio, EBV Epstein–Barr virus, HGB Hemoglobin, LDH Lactate dehydrogenase, DIC Disseminated intravascular coagulation, TG Triglycerides, PLT Platelets, ALT Alanine aminotransferase, AST Aspartate aminotransferase, @Ne Neutrophils granulocyte

ISSN: 1471-2431