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Table 4 Comparison of neonatal outcomes between the La Réunion OGP 2008–2013 and the EPIPAGE-2 2011 cohorts by subgroups of gestational age: multivariable stratified analysis

From: Mortality and severe morbidity of very preterm infants: comparison of two French cohort studies

Neonatal outcomes 24–26 WG 27–28 WG 29–31 WG
Death or severe morbiditya 2.3 (1.5–3.5) 1.5 (1.1–2.1) 1.3 (1.0–1.8)
Death 2.3 (1.6–3.4) 1.8 (1.2–2.8) 2.3 (1.4–3.8)
Severe morbidityb 1.7 (1.0–2.9) 1.4 (0.9–2.0) 1.1 (0.8–1.6)
Bronchopulmonary dysplasia 0.8 (0.5–1.2) 1.2 (0.8–1.8) 1.6 (1.0–2.5)
Necrotising enterocolitisc 1.4 (0.7–3.1) 1.8 (1.0–3.4) 1.4 (0.8–2.6)
Severe neurological injury 1.1 (0.7–1.7) 1.3 (0.8–2.2) 0.7 (0.4–1.2)
Medical patent ductus arteriosus 0.5 (0.3–0.7) 0.4 (0.3–0.6) 0.6 (0.4–1.0)
Surgical patent ductus arteriosus 1.0 (0.6–1.7) 1.9 (1.0–3.6) 2.0 (0.8–4.7)
Severe retinopathy
Late onset sepsis 0.7 (0.5–1.1) 0.7 (0.5–1.0) 0.5 (0.4–0.7)
  1. Data are adjusted odds ratios with 95% confidence intervals in parenthesis as determined by logistic regression modelling
  2. The reference cohort is EPIPAGE-2
  3. All the different models were adjusted on gestational age, gender, and a set of perinatal factors including maternal hypertension (chronic or pregnancy-induced), maternal diabetes (pre-gestational or gestational), antenatal steroid therapy, multiple birth, mode of delivery, outborn status, and 5-min Apgar score
  4. aBronchopulmonary dysplasia, necrotising enterocolitis or severe neurological injury
  5. bDefined as previously among survivors
  6. cSame adjustment as previously, except for maternal diabetes due to lack of power