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Table 3 Comparison of neonatal outcomes between the La Réunion OGP 2008–2013 and the EPIPAGE-2 2011 cohorts by subgroups of gestational age: bivariable stratified analysis

From: Mortality and severe morbidity of very preterm infants: comparison of two French cohort studies

Neonatal outcomes

Cohort

24–26 WG, % (n/N)

27–28 WG, % (n/N)

29–31 WG, % (n/N)

Death or severe morbiditya

OGP

74.3 (165/222)

44.0 (135/307)

15.5 (115/743)

EPIPAGE 2

63.2 (500/791)**

35.3 (297/842)**

12.5 (254/2036)*

Death

OGP

45.9 (102/222)

19.2 (59/307)

4.7 (35/743)

EPIPAGE 2

30.3 (240/791)***

12.1 (102/842)**

2.7 (54/2036)**

Severe morbidityb

OGP

55.3 (63/114)

32.5 (76/234)

11.8 (80/677)

EPIPAGE 2

48.2 (260/539)

27.7 (195/704)

10.5 (200/1899)

Bronchopulmonary dysplasia

OGP

25.7 (56/218)

19.9 (60/301)

6.8 (50/732)

EPIPAGE 2

32.0 (200/625)

16.8 (127/755)

4.2 (83/1972)**

Necrotising enterocolitis

OGP

6.9 (15/218)

7.3 (22/301)

3.6 (26/732)

EPIPAGE 2

4.6 (35/761)

5.2 (42/812)

2.6 (53/2006)

Severe neurological injury

OGP

23.9 (51/213)

10.8 (31/287)

3.9 (28/711)

EPIPAGE 2

26.2 (201/767)

11.4 (93/817)

5.4 (107/1993)

Medical patent ductus arteriosus

OGP

25.2 (55/218)

15.0 (45/301)

4.0 (29/733)

EPIPAGE 2

40.7 (304/747)***

33.0 (267/809)***

7.9 (155/1969)***

Surgical patent ductus arteriosus

OGP

16.5 (36/218)

8.3 (25/301)

2.0 (15/732)

EPIPAGE 2

18.6 (139/747)

5.3 (43/808)

0.9 (18/1956)*

Retinopathy

Yes

OGP

1.8 (4/222)

1.6 (5/307)

2.7 (20/743)

Missing data

 

70.7 (157/222)

73.6 (226/307)

73.1 (543/743)

Yes

EPIPAGE 2

3.7 (29/791)***

0.6 (5/842)***

0.1 (2/2036)***

Missing data

 

20.3 (161/791)

31.1 (262/842)

27.5 (560/2036)

Late onset sepsis

OGP

56.0 (122/218)

42.2 (127/301)

14.0 (102/726)

EPIPAGE 2

65.2 (473/726)*

49.4 (385/780)*

24.2 (450/1858)***

  1. aBronchopulmonary dysplasia, necrotising enterocolitis or severe neurological injury.bDefined as previously among survivors
  2. Data are numbers and percentages (calculated on actual denominators after exclusion of missing data)
  3. P values were calculated using a chi-squared test or a Fisher’s exact. *** P < 0.001; ** P < 0.01; and * P < 0.05