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Table 3 Comparison of neonatal outcomes between the La Réunion OGP 2008–2013 and the EPIPAGE-2 2011 cohorts by subgroups of gestational age: bivariable stratified analysis

From: Mortality and severe morbidity of very preterm infants: comparison of two French cohort studies

Neonatal outcomes Cohort 24–26 WG, % (n/N) 27–28 WG, % (n/N) 29–31 WG, % (n/N)
Death or severe morbiditya OGP 74.3 (165/222) 44.0 (135/307) 15.5 (115/743)
EPIPAGE 2 63.2 (500/791)** 35.3 (297/842)** 12.5 (254/2036)*
Death OGP 45.9 (102/222) 19.2 (59/307) 4.7 (35/743)
EPIPAGE 2 30.3 (240/791)*** 12.1 (102/842)** 2.7 (54/2036)**
Severe morbidityb OGP 55.3 (63/114) 32.5 (76/234) 11.8 (80/677)
EPIPAGE 2 48.2 (260/539) 27.7 (195/704) 10.5 (200/1899)
Bronchopulmonary dysplasia OGP 25.7 (56/218) 19.9 (60/301) 6.8 (50/732)
EPIPAGE 2 32.0 (200/625) 16.8 (127/755) 4.2 (83/1972)**
Necrotising enterocolitis OGP 6.9 (15/218) 7.3 (22/301) 3.6 (26/732)
EPIPAGE 2 4.6 (35/761) 5.2 (42/812) 2.6 (53/2006)
Severe neurological injury OGP 23.9 (51/213) 10.8 (31/287) 3.9 (28/711)
EPIPAGE 2 26.2 (201/767) 11.4 (93/817) 5.4 (107/1993)
Medical patent ductus arteriosus OGP 25.2 (55/218) 15.0 (45/301) 4.0 (29/733)
EPIPAGE 2 40.7 (304/747)*** 33.0 (267/809)*** 7.9 (155/1969)***
Surgical patent ductus arteriosus OGP 16.5 (36/218) 8.3 (25/301) 2.0 (15/732)
EPIPAGE 2 18.6 (139/747) 5.3 (43/808) 0.9 (18/1956)*
Retinopathy Yes OGP 1.8 (4/222) 1.6 (5/307) 2.7 (20/743)
Missing data   70.7 (157/222) 73.6 (226/307) 73.1 (543/743)
Yes EPIPAGE 2 3.7 (29/791)*** 0.6 (5/842)*** 0.1 (2/2036)***
Missing data   20.3 (161/791) 31.1 (262/842) 27.5 (560/2036)
Late onset sepsis OGP 56.0 (122/218) 42.2 (127/301) 14.0 (102/726)
EPIPAGE 2 65.2 (473/726)* 49.4 (385/780)* 24.2 (450/1858)***
  1. aBronchopulmonary dysplasia, necrotising enterocolitis or severe neurological injury.bDefined as previously among survivors
  2. Data are numbers and percentages (calculated on actual denominators after exclusion of missing data)
  3. P values were calculated using a chi-squared test or a Fisher’s exact. *** P < 0.001; ** P < 0.01; and * P < 0.05