From: An economic analysis of human milk supplementation for very low birth weight babies in the USA
Description | Base case [reference] | Sensitivity analysis | |
---|---|---|---|
Lower cost scenario | Higher cost scenario | ||
Probability of event in the usual practice of care group (%) | |||
Necrotising Enterocolitis Of which surgically treated | 16.7 [12] | 17.2 [5] | 16.7 [12] |
63.5 [12] | 68.8 [5] | 63.5 [12] | |
Late onset sepsis | 30.3 [12] | 34.4 [5] | 30.3 [12] |
Mortality (during initial hospital stay) | 17.2 [12] | 7.5 [5] | 17.2 [12] |
Bronchopulmonary dysplasia | 56.3 [12] | 30.1 [5] | 56.3 [12] |
Retinopathy of prematurity | 9.0 [12] | 10.7 [13] | 9.0 [12] |
Relative risk of event in EHMD group | |||
Necrotising Enterocolitis | 0.31 [5] | 0.31 [5] | 0.41 [12] |
Late onset sepsis | 0.87 a [5] | 0.63 [12] | 0.87 a [5] |
Mortality (during initial hospital stay) | 0.79 [12] | 0.79 [12] | 0.24 [5] |
Bronchopulmonary dysplasia | 0.99 [5] | 0.85 [12] | 0.99 [5] |
Retinopathy of prematurity | 0.15 [13] | 0.15 [13] | 0.58 [12] |
Probability of event independent of treatment group (%) | |||
Short bowel syndrome (following surgical NEC only) | 15.7 [14] | – | – |
Cerebral palsyb | |||
No NEC or late onset sepsis | 14.8c [15] | – | – |
Following late onset sepsis | 14.8c [15] | – | – |
Following NEC (odds ratio) | 1.55 [15] | – | – |
Reduction in IQ points following: | |||
NEC | 11 [16] | – | – |
Late onset Sepsis | 9 [17] | – | – |