Table 6 Monte Carlo Simulation Results for Neonates Weighing Between 851 and 1200 g
Dosing Regimen | Target Peak Serum Concentration (mg/L) | Target Trough Serum Concentration (mg/L) | Peak: Minimum Inhibitory Concentration Ratio | |||||
|---|---|---|---|---|---|---|---|---|
Dose (mg/kg) | Dosing Interval (h) | 5–10 | 12–20 | 15–20 | ≥ 20 | ≤ 2 | ≤ 0.5 | ≥ 8 |
2.5a | 24 | 66.21% | 0.00% | 0.00% | 0.00% | 99.66% | 27.12% | 3.27% |
3.5a | 24 | 91.17% | 0.83% | 0.02% | 0.00% | 96.57% | 9.94% | 9.39% |
2.5 | 24 | 66.21% | 0.00% | 0.00% | 0.00% | 99.66% | 27.12% | 3.27% |
3.0 | 24 | 90.28% | 0.06% | 0.00% | 0.00% | 98.68% | 16.37% | 6.08% |
3.5b | 24 | 91.17% | 0.83% | 0.02% | 0.00% | 96.57% | 9.94% | 9.39% |
4.0 | 24 | 77.21% | 4.42% | 0.21% | 0.00% | 93.13% | 6.17% | 13.23% |
4.5 | 24 | 55.29% | 13.88% | 1.23% | 0.01% | 88.39% | 4.01% | 17.50% |
4.5 | 36 | 72.05% | 5.81% | 0.27% | 0.00% | 99.96% | 69.44% | 14.27% |
5.0 | 36 | 50.61% | 15.89% | 1.38% | 0.00% | 99.90% | 62.85% | 18.27% |
5.5 | 36 | 30.74% | 31.43% | 4.51% | 0.05% | 99.80% | 56.50% | 22.73% |
6.0 | 36 | 16.46% | 49.27% | 10.87% | 0.28% | 99.66% | 50.67% | 27.44% |
6.5 | 36 | 7.96% | 65.32% | 20.63% | 0.96% | 99.42% | 45.56% | 32.25% |
7.0 | 36 | 3.50% | 76.80% | 32.38% | 2.61% | 99.08% | 40.71% | 37.26% |
7.5 | 36 | 1.43% | 82.50% | 43.50% | 5.85% | 98.62% | 36.70% | 42.38% |
8.0 | 36 | 0.56% | 82.76% | 52.04% | 11.15% | 98.06% | 32.80% | 47.42% |
8.5 | 36 | 0.21% | 78.31% | 56.09% | 18.62% | 97.40% | 29.56% | 52.36% |
9.0 | 36 | 0.07% | 70.46% | 55.41% | 28.09% | 94.61% | 21.62% | 66.33% |
7.5 | 48 | 14.52% | 81.31% | 39.39% | 4.12% | 99.99% | 89.88% | 40.26% |
8.0c | 48 | 7.95% | 83.70% | 49.22% | 8.35% | 99.99% | 88.06% | 45.22% |
8.5c | 48 | 4.07% | 81.27% | 55.18% | 14.72% | 99.98% | 86.11% | 50.20% |
9.0c | 48 | 2.00% | 74.96% | 56.71% | 23.04% | 99.96% | 84.10% | 54.91% |
9.5 | 48 | 0.94% | 66.18% | 54.11% | 32.88% | 99.95% | 82.15% | 59.48% |
10 | 48 | 0.43% | 56.10% | 48.53% | 43.50% | 99.93% | 80.12% | 63.87% |