Optimizing gentamicin conventional and extended interval dosing in neonates using Monte Carlo simulation – a retrospective study

Table 4 Mean pharmacokinetic parameters

	≤ 850 g			851–1200 g			> 1200 g			p-value^a
	n = 25 gentamicin levels in 25 patients^b			n = 24 gentamicin levels in 23 patients^b			n = 15 gentamicin levels in 13 patients			Overall p-value	≤ 850 g vs 851 − 1200 g	≤ 850 g vs > 1200 g	851 − 1200 g vs > 1200 g
	Mean	95% Confidence Interval	Range	Mean	95% Confidence Interval	Range	Mean	95% Confidence Interval	Range	Overall p-value	≤ 850 g vs 851 − 1200 g	≤ 850 g vs > 1200 g	851 − 1200 g vs > 1200 g
Elimination rate constant (h⁻¹)	0.06415	0.05762–0.07068	0.0456–0.1139	0.09087	0.08447–0.09728	0.0652–0.1327	0.09734	0.08519–0.10948	0.05693–0.14332	< 0.0001	< 0.001	< 0.001	> 0.05
Half-life (h)	10.8	9.8–11.8	6.1–15.2	7.6	7.1–8.2	5.2–10.6	7.1	6.0–8.2	4.8–12.2	–	–	–	–
Volume of distribution (L)	0.36	0.33–0. 39	0.22–0.51	0.51	0.46–0.57	0.33–0.87	0.88	0.76–1.00	0.53–1.23				–
Volume of distribution (L/kg)	0.55	0.50–0.60	0.35–0.83	0.50	0.46–0.54	0.38–0.76	0.52	0.43–0.61	0.26–0.96	0.2471	–	–	–
Clearance (L/h)	0.023	0.021–0.025	0.016–0.038	0.047	0.041–0.053	0.028–0.086	0.086	0.070–0.101	0.040–0.137	–	–	–	–
Clearance (L/h/kg)	0.035	0.032–0.038	0.026–0.056	0.045	0.041–0.049	0.032–0.067	0.050	0.043–0.058	0.028–0.081	< 0.0001	< 0.01	< 0.001	> 0.05

Multiple Comparison Test for data that did not pass the test for normality
^aANOVA with Tukey-Kramer Multiple Comparisons Test for data that passed the test for normality or a Kruskal-Wallis Test with Dunn’s Multiple Comparison Test for data that did not pass the test for normality
^bOne patient contributed 1 set of gentamicin levels to weight categories ≤ 850 g and 851-1200 g
Bold data indicates statistically significant p-values for a given parameter with either bivariate or multivariable analysis

ISSN: 1471-2431