Optimizing gentamicin conventional and extended interval dosing in neonates using Monte Carlo simulation – a retrospective study

Table 3 Bivariate and Multivariable Analysis

Parameter^a	Clearance (L/h)		Volume of Distribution (L)
Parameter^a	Bivariate p-value	Multivariable p-value	Bivariate p-value	Multivariable p-value
Post-natal age (Days) at gentamicin initiation	< 0.0001	0.0001	0.0037	0.0563
Gender	0.0311	0.0447	0.0667	–
Weight at gentamicin initiation (g)	< 0.0001	< 0.0001	< 0.0001	< 0.0001
Blood urea nitrogen at baseline (mmol/L)	< 0.0001	0.5855	< 0.0001	0.6643
Serum creatinine at baseline (μmol/L)	< 0.0001	0.0569	0.0011	0.4553
Concomitant nephrotoxins	0.0154	0.9332	0.0279	0.8204

^aBaseline values needed to be reported within 14 days prior to the initiation of gentamicin; if unavailable, first value taken during course of gentamicin was used as a surrogate
Bold data indicates statistically significant p-values for a given parameter with either bivariate or multivariable analysis

ISSN: 1471-2431