Optimizing gentamicin conventional and extended interval dosing in neonates using Monte Carlo simulation – a retrospective study

Table 2 Bacterial Isolates Cultured at Time of Gentamicin Initiation

Number of gentamicin treatment courses		64 (4 patients had 2 separate gentamicin treatment courses)
Number of gentamicin treatment courses with a positive culture (%)		24 (37.5)
Number of gentamicin treatment courses that were Polymicrobial (2 or more bacterial isolates) (%)		7 (10.9)
	Total Number of Isolates n = 36 (%)^a	Source of Culture
	Total Number of Isolates n = 36 (%)^a	Blood	Cerebrospinal Fluid	Endotracheal Tube	Urine	Eye	Skin
Escherichia coli	7 (19)	4 (11)	1 (3)	1 (3)	1 (3)	0	0
Klebsiella species	5 (14)	1 (3)	0	2 (6)	2 (6)	0	0
Pseudomonas species	2 (6)	0	0	1 (3)	0	1 (3)	0
Enterobacter species	1 (3)	0	0	0	0	0	1 (3)
Raoultella species	1 (3)	0	0	0	0	0	1 (3)
Gram-positive organisms^b	15 (42)	7 (19)	1 (3)	1 (3)	3 (9)	1 (3)	2 (6)
Other^c	5 (14)	0	0	5 (14)	0	0	0

^a All percentages are determined from total isolates (n = 36)
^b Total of 15 g positive organisms include coagulase-negative Staphylococcus (12); Enterococcus species (1); Staphylococcus aureus (1) Group B Streptococcus (1)
^cTotal of 5 ‘Other’ organisms include Mycoplasma spp (1) and Ureaplasma urealyticum (4)

ISSN: 1471-2431