Fig. 1

Clinical pictures of this patient. a: Tooth delay or tooth agenesis was found at the age of 2 years and 6 months old; b: Body examination indicated manifestation of polytrichia; c: Brain MRI showed the extra cerebral space widening at six months old; d-f: Frontotemporal space widening, delayed myelination or hypomyelination of white matter in the focal area around the posterior horn of the bilateral lateral ventricles at the age of eleven months. g: Fiberoptic bronchoscopy presented the absence of right middle bronchus orifice