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Table 2 Performance comparison of study developed tool to currently published screening tools [5,6,7,8,9,10,11,12,13,14]

From: Development, evaluation and validation of a screening tool for late onset bacteremia in neonates – a pilot study

 

Sensitivity

Specificity

Period Prevalence

Positive Post-Test Probability

Negative Post-Test Probability

Positive Likelihood Ratio

Negative Likelihood Ratio

False Positive rate

False Negative Rate

Study Developed Tool Negative Post-Test Probability at Citation Bacteremia Period Prevalence

Study Developed Tool

P value > 0.415

0.90

0.80

0.51

0.82

0.11

4.50

0.12

0.20

0.10

Mahieu et al., 2000 [7]

 Score ≥ 8

0.95

0.43

0.41

0.54

0.08

1.67

0.12

0.57

0.05

0.08

 Score ≥ 11

0.60

0.84

0.41

0.72

0.25

3.75

0.48

0.16

0.40

0.08

 Score ≥ 14

0.26

1.00

0.41

1.00

0.34

9999.00

0.74

0.00

0.74

0.08

 Score ≥ 11 plus positive culture

0.72

0.87

0.41

0.79

0.18

5.50

0.32

0.13

0.28

0.08

Mahieu et al., 2002 [5]

 Score ≥ 11

0.84

0.42

0.55

0.64

0.32

1.45

0.38

0.58

0.16

0.13

 Score ≥ 11 + 3 RFs

0.82

0.67

0.55

0.75

0.25

2.48

0.27

0.33

0.18

0.13

Singh et al., 2003 [8]

 Score ≥ 1

0.87

0.29

0.29

0.33

0.16

1.23

0.45

0.71

0.13

0.05

 Score ≥ 2

0.53

0.80

0.29

0.52

0.19

2.65

0.59

0.20

0.47

0.05

Okascharoen et al., 2005 [9]

 Score ≥ 4

0.82

0.74

0.17

0.39

0.05

3.15

0.24

0.26

0.18

0.02

 Score ≥ 5

0.70

0.82

0.17

0.44

0.07

3.89

0.37

0.18

0.30

0.02

 Score ≥ 6

0.47

0.96

0.17

0.71

0.10

12.00

0.55

0.04

0.53

0.02

Dalgic et al., 2006 [10]

 Score = 6–12

0.56

0.71

0.39

0.55

0.28

1.93

0.62

0.29

0.44

0.07

Okascharoen et al., 2007 [6]

 Validation Cohort Score ≤ 3 (low risk of sepsis)

0.97

0.39

0.33

0.43

0.40

1.6

0.07

0.61

0.03

0.06

 Validation Cohort Score 4–7 (medium risk of sepsis)

0.77

0.43

0.33

0.48

0.27

1.35

0.53

0.57

0.23

0.06

 Validation Cohort Score ≥ 8 (high risk of sepsis)

0.2

0.98

0.33

0.99

0.85

10

0.82

0.02

0.8

0.06

Kudawla et al., 2008 [11]

 ≥1 clinical signs

0.90

0.23

0.27

0.30

0.14

1.17

0.43

0.77

0.10

0.04

 ≥2 clinical signs

0.52

0.65

0.27

0.36

0.21

1.49

0.74

0.35

0.48

0.04

 ≥2 markers

0.48

0.70

0.27

0.37

0.21

1.60

0.74

0.30

0.52

0.04

 ≥1 clinical sign + ≥ 2 markers

0.95

0.18

0.27

0.30

0.09

1.16

0.28

0.82

0.05

0.04

Rosenberg et al., 2010 [12]

 Score ≥ 1

0.77

0.50

0.54

0.64

0.35

1.54

0.46

0.50

0.23

0.12

 Score ≥ 2

0.42

0.82

0.54

0.73

0.45

2.33

0.71

0.18

0.58

0.12

Bekhof et al., 2013 [13]

 1 of 4 signs present

0.97

0.37

0.27

0.36

0.03

1.54

0.08

0.63

0.03

0.04