From: Clinical manifestations and anti-TNF alpha therapy of juvenile Behçet’s disease in Taiwan
Case | Sex | Previous treatments | Duration of steroid use before aTNF (years) | Type of aTNF | Duration of aTNF (years) | Reasons for use of aTNF | Treatment responses | Side effects |
---|---|---|---|---|---|---|---|---|
#1 | F | PD, AZA | 7.0 | ETN | 3.2 | Frequent fever, oral ulcer, enteritis. Frequent hospitalizations. | Fever subsided and ESR level returned to normal range within 1 year. Steroid was discontinued for 2.8 years. One BD flare after tapering ETN. | Herpes zoster, pneumonia |
#2 | F | PD, 5-ASA, colchicine | 3.3 | ETN | 2.4 | Steroid-dependent disease status with oral ulcers and GI bleeding. | Hgb and CRP level returned to normal range within 4 months. Steroid was discontinued 6 months later. One BD flare after tapering ETN | None |
#3 | F | PD, AZA Colchicine | 1.6 | ADA | 1.0 | Recurrent uveitis, oral and genital ulceration. | Improved uveitis and vessel leakage. VA remained stationary. | None |
#4 | M | PD, AZA | 0.6 | ETN | 7.8 | Refractory oral ulcer, gastrointestinal symptoms. | Improved clinical symptoms; CRP and ESR returned to normal range. PD and AZA were discontinued within 1 year. | Recurrent sinusitis |
#5 | M | PD, HCQ, CsA, AZA | 0.8 | ADA | 1.4 | Steroid-dependent uveitis. | Uveitis subsided with VA improvement. Persistent oral ulcer, high ESR and CRP levels. | None |
#6 | M | PD, 5-ASA | 5.8 | ETN | 2.7 | Neurologic involvement. Steroid dependent disease status with poor drug compliance. | Improved arthralgia, oral ulcer and bloody stool. CRP level returned to normal range. All drugs were discontinued after 6 months. | None |