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Table 1 Characteristics of the randomized controlled trials of different immunotherapies for neonates with suspected or proven sepsis

From: Effects of immunotherapy on mortality in neonates with suspected or proven sepsis: a systematic review and network meta-analysis

First author of publication

Number of participants (n)

Participants

Interventions

Outcomes

Treatment (male)

Control 1 (male)

Control 2 (male)

Treatment

Control 1

Control 2

Ahmad (2002) [27]

28

10 (NA)

10 (NA)

8 (NA)

G-CSF

5 μg/kg/12 h, IV, 7 days or until ANC ≥ 10000 cells/mm3

GM-CSF

4 μg/kg/12 h, IV, 7 days or until ANC ≥ 10000 cells/mm3

Placebo

All-cause mortality; hospital stay duration

Ahmed (2006) [28]

60

30 (15)

30 (16)

 

IgG

500 mg/kg/d, IV, 3 days

No intervention

 

All-cause mortality; hospital stay duration

Akdag (2014) [29]

102

51 (30)

51 (31)

 

IgGAM

250 mg/kg/d, IV, 3 days

Placebo (saline)

 

All-cause mortality; hospital stay duration

Aktas (2015) [30]

56

33 (23)

23 (17)

 

G-CSF

10 μg/kg/d, until ANC ≥ 1.0 × 109/L

No intervention

 

All-cause mortality

Bedford Russell (2001) [31]

28

13 (3)

15 (4)

 

G-CSF

10 μg/kg/d, IV, maximum of 14 days

Placebo

 

All-cause mortality; mechanical ventilation days;

ICU stay duration

Bilgin (2001) [32]

60

30 (17)

30 (18)

 

GM-CSF

5 μg/kg/d, IH, 7 days

No intervention

 

All-cause mortality; hospital stay duration

Borjianyazdi (2013) [33]

46

23 (12)

23 (14)

 

GCSF

10 μg/kg/d, IH, 5 days

Placebo (saline)

 

All-cause mortality; hospital stay duration

Chaudhuri (2012) [34]

78

39 (22)

39 (24)

 

GCSF

10 μg/kg/d, IV, 3 days

Placebo (5% dextrose)

 

All-cause mortality

Chen (1996) [35]

56

28 (NA)

28 (NA)

 

IgG

500 mg/kg, one dose

Placebo (0.9% sodium chloride)

 

All-cause mortality

Christensen (1991) [36]

22

11 (NA)

11 (NA)

 

IgG

750 mg/kg, IV, one dose

Placebo (albumin)

 

All-cause mortality

Drossou-Agakidou (1998) [37]

35

19 (NA)

16 (NA)

 

G-CSF

10 lg/kg/d, IH, 3 days

No intervention

 

All-cause mortality

Drossou-Agakidou (2002) [38]

56

17 (8)

19 (9)

20 (13)

GM-CSF

5 mcg/kg/d, IV, 4 days

G-CSF

10 mcg/kg/d, IV, 4 days

Placebo (saline)

All-cause mortality; hospital stay duration;

mechanical ventilation days

El-Ganzoury (2012) [39]

60

30 (15)

30 (16)

 

G-CSF

10 μg/kg/d, IV, 3 days

No intervention

 

All-cause mortality; hospital stay duration;

mechanical ventilation days

Erdem (1993) [40]

44

20 (NA)

24 (NA)

 

IgGAM

5 ml/kg/d, IV, 3 days

No intervention

 

All-cause mortality

Gathwala (2012) [18]

40

20 (11)

20 (13)

 

G-CSF

10 mg/kg/d, IV, 5 days

No intervention

 

All-cause mortality; hospital stay duration

Gunes (2006) [41]

88

33 (18)

33 (12)

 

IgG

500 mg/kg, IV

No intervention

 

All-cause mortality

Haque (1988) [42]

60

30 (20)

30 (24)

 

IgGAM

5 mL/kg/d, IV, 4 days

Placebo (10% dextrose)

 

All-cause mortality

Haque (1995) [43]

195

65 (NA)

65 (NA)

65 (NA)

IgG

250 mg/kg/d, IV, 4 days

IgGAM, pentaglobin

250 mg/kg/d, IV, 4 days

no intervention

All-cause mortality

INIS Collaborative Group (2011) [17]

3493

1759 (NA)

1734(NA)

 

IgG

500 mg/kg/48 h, IV, 2 doses

Placebo (saline/ albumin solution)

 

All-cause mortality; hospital stay duration

Kucukoduk (2002) [44]

40

20 (12)

20 (11)

 

G CSF

5 μg/kg/d, IV, 3 days

Placebo (physiological serum)

 

All-cause mortality; ICU stay duration

Mancilla-Ramirez (1992) [45]

37

19 (NA)

18 (NA)

 

IgG

500 mg/kg, IV, one dose

Placebo (maltose)

 

All-cause mortality

Miura (2000) [46]

44

22 (9)

22 (14)

 

G-CSF

10 μg/kg/d, IV, 3 days

Placebo

 

All-cause mortality

Samatha (1997) [47]

60

30 (NA)

30 (NA)

 

IgGAM

5 mL/kg/d, 3 days

No intervention

 

All-cause mortality; hospital stay duration

Schibler (1998) [48]

20

10 (6)

10 (7)

 

G-CSF

10 μg/kg/d, IV, 3 days

Placebo

 

All-cause mortality

Shenoi (1999) [49]

57

25 (18)

25 (20)

7 (5)

IgG

1 g/kg, IV, 3 days

Placebo (0.15%

saline in 10% dextrose)

no intervention

All-cause mortality; hospital stay duration;

mechanical ventilation days

Sidiropoulos (1981) [50]

82

41 (NA)

41 (NA)

 

IgG

preterm infants: 0.5 g/d, 6 days;

term infants: 1.0 g/d, 6 days

No intervention

 

All-cause mortality

Weisman (1992) [51]

31

14 (7)

17 (10)

 

IgG

500 mg/kg, IV

Placebo (albumin)

 

All-cause mortality; hospital stay duration

  1. IgG immunoglobulin, IgGAM IgM-enriched immunoglobulin, G-CSFs granulocyte-colony stimulating factor, GM-CSF granulocyte-macrophage colony stimulating factor, IVIg intravenous immunoglobulin