Severity of hypoxic ischemic encephalopathy and heart rate variability in neonates: a systematic review

BMC Pediatrics

Table 1 Gestational age, birth weight, and male to female ratio of the neonates in the four studies on hypoxic ischemic encephalopathy (HIE) and heart rate variability

	HIE severity	Number of neonates	Gestational age (weeks)	Birth weight (g)	M/F-ratio
Aliefendioglu et al. 2012, Turkey [19]	Severe HIE Moderate HIE	10 12	39 (0.78) ^a 39 (0.72) ^a	3500 (515) ^a 3433 (557) ^a	6/4 8/4
	No HIE	24	39 (0.88) ^a	3283 (379) ^a	14/10
Vergales et al. 2013, USA [20]	Severe, moderate, mild, and no HIE	67	38 (1.4) ^a	3236 (511) ^a	NDA
Goulding et al. 2015, Ireland [21]	Severe, moderate, and mild HIE	44	39 (36, 42) ^b	3384 (1830, 5040) ^b	26/18
	No HIE	17	40 (38, 41) ^b	3601 (2980, 4060) ^b	11/6
Goulding et al. 2017, Ireland [22]	Severe, moderate, and mild HIE	74	40 (39, 41) ^c	3425 (3165, 3745) ^c	40/34

^a Values are presented as mean (standard deviation). ^b Values are presented as mean (minimum to maximum)
^c Values are presented as median (lower to upper quartile)
M/F-ratio, male to female ratio; NDA, no data available

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