Table 1 Summary of hemoglobin M diseases presenting as neonatal cyanosis
Reference | Form of genetic variation | Hemoglobin subunit | MetHb level estimated by co-oximetry | Hemoglobin variants |
|---|---|---|---|---|
Viana et al., 2014 [1] | De novo mutation | Alpha 2 | 12.5% | Hb M Iwate |
Estey et al., 2015 [2] | Familial | Alpha 2 | Measuring error | Hb M Boston |
Elboraee et al., 2015 [5] | Familial | Alpha 2 | Measuring error | Hb M Boston |
Upadhye et al., 2015 [11] | Familial | Alpha | 13% | Hb M Boston |
Alonso-Ojembarrena et al., 2016 [14] | Familial | Gamma | 12.3% | Hb M Osaka |