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Table 2 Factors associated with blood gases (PaO2, PaCO2) and pH variations pre and post surfactant administration and in each of the four subsequent days. Data are expressed as coefficients and 95% CI

From: A shared protocol for porcine surfactant use in pediatric acute respiratory distress syndrome: a feasibility study

Associated factors PaO2 PaCO2 pH
Age −0.06 (− 0.05–0.01) 0.00 (− 0.01–0.02) 0.00 (0.00–0.00)
CCC 10.05 (−3.70–23.80) −1.97 (−  8.76–4.83) −0.02 (− 0.06–0.02)
Prematurity 14.21 (2.42–26.02)* 0.72 (− 4.32–5.77) −0.003 (− 0.05–0.04)
HFOV − 16.48 (− 28.77 - -4.18)* 9.44 (2.29–16.59)* −0.08 (− 0.13 - -0.02)*
iNO −12.16 (− 24.60–0.27) 6.78 (− 0.18–13.75) − 0.01 (− 0.07–0.05)
P-S 10.29 (−2.89–23.48) −4.64 (− 12.87–3.59) 0.02 (− 0.06–0.10)
Time interval adm - surf −0.02 (− 0.26–0.21) 0.19 (− 0.04–0.42) −0.001 (− 0.00–0.00)
Outcome −19.55 (− 34.28 - -4.84)* 5.60 (− 2.63–13.85) −0.003 (− 0.09–0.09)
  1. CCC Chronic Complex Condition, HFOV high frequency oscillatory ventilation, iNO inhaled nitric oxide, P-S prono supination, adm admission, surf surfactant dose; * = p < 0.05.
  2. Multivariate models of analysis of variance for repeated measures were fitted to find associations between demographic or clinical factors and each blood gas or pH variations. Results are presented with term specific p-values; the coefficient represents the mean variation of outcomes for unit change of quantitative predictors or between levels of categorical or ordinal predictors.