A shared protocol for porcine surfactant use in pediatric acute respiratory distress syndrome: a feasibility study

Table 2 Factors associated with blood gases (PaO₂, PaCO₂) and pH variations pre and post surfactant administration and in each of the four subsequent days. Data are expressed as coefficients and 95% CI

Associated factors	PaO2	PaCO2	pH
Age	−0.06 (− 0.05–0.01)	0.00 (− 0.01–0.02)	0.00 (0.00–0.00)
CCC	10.05 (−3.70–23.80)	−1.97 (− 8.76–4.83)	−0.02 (− 0.06–0.02)
Prematurity	14.21 (2.42–26.02)*	0.72 (− 4.32–5.77)	−0.003 (− 0.05–0.04)
HFOV	− 16.48 (− 28.77 - -4.18)*	9.44 (2.29–16.59)*	−0.08 (− 0.13 - -0.02)*
iNO	−12.16 (− 24.60–0.27)	6.78 (− 0.18–13.75)	− 0.01 (− 0.07–0.05)
P-S	10.29 (−2.89–23.48)	−4.64 (− 12.87–3.59)	0.02 (− 0.06–0.10)
Time interval adm - surf	−0.02 (− 0.26–0.21)	0.19 (− 0.04–0.42)	−0.001 (− 0.00–0.00)
Outcome	−19.55 (− 34.28 - -4.84)*	5.60 (− 2.63–13.85)	−0.003 (− 0.09–0.09)

CCC Chronic Complex Condition, HFOV high frequency oscillatory ventilation, iNO inhaled nitric oxide, P-S prono supination, adm admission, surf surfactant dose; * = p < 0.05.
Multivariate models of analysis of variance for repeated measures were fitted to find associations between demographic or clinical factors and each blood gas or pH variations. Results are presented with term specific p-values; the coefficient represents the mean variation of outcomes for unit change of quantitative predictors or between levels of categorical or ordinal predictors.

ISSN: 1471-2431