Skip to main content

Table 2 Hemodynamic changes at specific timing points

From: Baseline cardiac output and its alterations during ibuprofen treatment for patent ductus arteriosus in preterm infants

   Responders (n = 9) Non-responders (n = 9) p value
COEC (ml/kg/min) Prior to dose #1 250 ± 31 282 ± 21 0.022b
No ductal flowa 225 ± 17c N/A N/A
18–24 h after dose #3 232 ± 15 270 ± 39 0.021b
HREC (beats/min) Prior to dose #1 157 ± 7 160 ± 8 0.394
No ductal flowa 151 ± 7 N/A N/A
18–24 h after dose #3 153 ± 8 160 ± 6 0.077
SVEC (ml/kg) Prior to dose #1 1.59 ± 0.23 1.77 ± 0.30 0.165
No ductal flowa 1.50 ± 0.15 N/A N/A
18–24 h after dose #3 1.63 ± 0.29 1.63 ± 0.25 0.926
  1. CO cardiac output, HR heart rate, SV stroke volume, EC electrical cardiometry, N/A not applicable
  2. Data are mean (± SD)
  3. aFive infants’ ductal flow disappeared in color Doppler post dose #1, two post dose #2 and two post dose #3
  4. bindicates statistical significance between responders and non-responders (independent t-test)
  5. cindicates statistical significance comparing to baseline value prior to dose #1 (paired t-test)