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Table 2 Hemodynamic changes at specific timing points

From: Baseline cardiac output and its alterations during ibuprofen treatment for patent ductus arteriosus in preterm infants

  

Responders (n = 9)

Non-responders (n = 9)

p value

COEC (ml/kg/min)

Prior to dose #1

250 ± 31

282 ± 21

0.022b

No ductal flowa

225 ± 17c

N/A

N/A

18–24 h after dose #3

232 ± 15

270 ± 39

0.021b

HREC (beats/min)

Prior to dose #1

157 ± 7

160 ± 8

0.394

No ductal flowa

151 ± 7

N/A

N/A

18–24 h after dose #3

153 ± 8

160 ± 6

0.077

SVEC (ml/kg)

Prior to dose #1

1.59 ± 0.23

1.77 ± 0.30

0.165

No ductal flowa

1.50 ± 0.15

N/A

N/A

18–24 h after dose #3

1.63 ± 0.29

1.63 ± 0.25

0.926

  1. CO cardiac output, HR heart rate, SV stroke volume, EC electrical cardiometry, N/A not applicable
  2. Data are mean (± SD)
  3. aFive infants’ ductal flow disappeared in color Doppler post dose #1, two post dose #2 and two post dose #3
  4. bindicates statistical significance between responders and non-responders (independent t-test)
  5. cindicates statistical significance comparing to baseline value prior to dose #1 (paired t-test)
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BMC Pediatrics

ISSN: 1471-2431

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