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Table 1 Comparison of FASD guideline features that relate to the neurodevelopmental assessment

From: Accuracy of motor assessment in the diagnosis of fetal alcohol spectrum disorder

Guideline Diagnostic terms Cut-off score to indicate a severe impairment Total scores or subtests Evidence of pervasive brain dysfunction
Canadian Guideline (2016) [5] FASD with Sentinel Facial Features, FASD without Sentinel Facial Features -2SD Composite score or multiple subtest scores Severe impairment in 3 or more of 10 neurodevelopment domains
Australian Guide (2016) [13] FASD with 3 Sentinel Facial Features, FASD with < 3 Sentinel Facial Features -2SD Composite score or 1 or more major subdomain scores Severe impairment in at least 3 neurodevelopmental domains
Updated Clinical Guidelines (2016) [15] FAS, Partial FAS, ARND, ARBD -1.5SD Not specified Impairment in at least 1 neurodevelopmental domain
University of Washington 4 Digit Code (2004) [14] FAS, Partial FAS, ARND -2SD Not specified Severe dysfunction in 3 or more domains of function
CDC Diagnostic Guidelines (2004) [16] FAS -1SD Not specified Deficit in 3 or more functional domains
  1. Other factors not listed in this table contribute to the diagnoses listed above, such as confirmation of prenatal alcohol exposure, facial features, growth and structural abnormalities
  2. Canadian Guideline = Fetal alcohol spectrum disorder: a guideline for diagnosis across the lifespan, Australian Guide = Australian Guide to the diagnosis of Fetal Alcohol Spectrum Disorder (FASD), Updated Clinical Guidelines = Updated Clinical Guidelines for Diagnosing Fetal Alcohol Spectrum Disorders, University of Washington 4 Digit Code = Diagnostic Guide for Fetal Alcohol Spectrum Disorders: The 4-Digit Diagnostic Code, 3rd Edition, CDC Diagnostic Guidelines = Center for Disease Control and Prevention’s Fetal Alcohol Syndrome: Guidelines for Referral and Diagnosis, FASD Fetal Alcohol Spectrum Disorder, FAS Fetal Alcohol Syndrome, PFAS Partial Fetal Alcohol Syndrome, ARND Alcohol-Related Neurodevelopmental Disorder, ARBD Alcohol-Related Birth Defects, SD Standard Deviation from the mean