A multi-center clinical investigation on invasive Streptococcus pyogenes infection in China, 2010–2017

BMC Pediatrics

Table 2 The clinical manifestation and antibiotics for therapy in the 66 patients with invasive S. pyogenes infection

Clinical manifestation	N	%	Treatment with antibiotics	N	%
Meningitis with cerebral trauma	1	1.5	^a Penicillins or/ and Cephalosporins	27	40.9
Pneumonia with pleural effusion	1	1.5	Carbapenems + vancomycin	7	10.6
Sepsis (64 cases, 97.0%)			Carbapenems, penicillin	3	4.6
Skin / soft tissue infections	21	31.8	Vancomycin + cephalosporins, Cephalosporins	3	4.6
Severe pneumonia (4 with pleural effusion)	10	15.2	Vancomycin	2	3.0
Suppurative arthritis and osteomyelitis	6	9.1	Carbapenems	2	3.0
Both Pneumonia and skin / soft tissue infections (1 with pleural effusion)	6	9.1	Carbapenems, Cephalosporins	2	3.0
Suppurative tonsillitis	3	4.5	Vancomycin + cephalosporins	2	3.0
Meningitis	3	4.5	Carbapenems + vancomycin, vancomycin	2	3.0
Skin / soft tissue infections, suppurative arthritis, osteomyelitis and necrotising fasciitis	2	3.0	Carbapenems + vancomycin, Vancomycin + cephalosporins	2	3.0
Both pneumonia and meningitis	1	1.5	Vancomycin + cephalosporins, Penicillin	2	3.0
Both skin / soft tissue infections and meningitis	1	1.5	^bOther regimen	10	15.3
Both mastoiditis and otitis media	1	1.5	No antibiotics	2	3.0
Without identified focus	10	15.3
Total	66	100	Total	66	100

^aPenicillins (4 cases); Cephalosporins (13 cases); Penicillins + Cephalosporins (5 cases); Cephalosporins, penicillins (5 cases)
^bClindamycin, azithromycin (1 case); azithromycin, vancomycin (1 case); Carbapenems+ linezolid, penicillin + linezolid (1 case); Carbapenems + vancomycin, lynezolid (1 case); Carbapenems + vancomycin, penicillin + lynezolid (1 case); Carbapenems + vancomycin, cephalosporins (1 case); Carbapenems, lynezolid (1 case); Carbapenems + vancomycin, vancomycin, cephalosporins (1 case); Vancomycin + cephalosporins, penicillin (1 case); Vancomycin + penicillin, penicillin (1 case)

ISSN: 1471-2431