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Table 3 Diagnostic value of cerebrospinal fluid markers (CD64in, leukocyte count, percentage of neutrophils, glucose, and proteins, and blood markers (leukocyte count, percentage of neutrophils and band neutrophils, CRP, and PCT) for bacterial ventriculitis

From: Neutrophil CD64 index in cerebrospinal fluid as a marker of bacterial ventriculitis in children with external ventricular drainage

 

Optimum diagnostic cut-off level

AUC (95% CI)

Sensitivity (%)

Specificity (%)

PPV (%)

NPV (%)

Cerebrospinal fluid markers

 CD64in

1.29

0.875 (0.713–0.963)

92

75

71

94

 Leukocyte count (×106/L)

187

0.694 (0.507–0.844)

69

68

60

77

 Percentage of N (%)

35

0.615 (0.428–0.781)

92

47

55

90

 Glucose (mmol/L)

2.1

0.666 (0.478–0.822)

77

53

53

77

 Proteins (g/L)

0.41

0.658 (0.470–0.815)

100

32

50

100

Blood markers

 Leukocyte count (×109/L)

14.4

0.504 (0.325–0.682)

39

95

83

70

 Percentage of N (%)

55

0.694 (0.496–0.850)

50

82

67

70

 Percentage of BN (%)

2

0.721 (0.524–0.870)

50

100

100

74

 CRP (mg/L)

5

0.792 (0.616–0.913)

85

75

69

88

 PCT (μg/L)

0.17

0.716 (0.507–0.873)

85

54

65

78

  1. AUC – area under the receiver operating curve, CI – confidence interval, PPV – positive predictive value, NPV – negative predictive value, CD64in – neutrophil CD64 index, N – neutrophils, BN – band neutrophils, CRP – C-reactive protein, PCT – procalcitonin