Fig. 2From: The various clinical spectra of juvenile xanthogranuloma: imaging for two case reports and review of the literatureHistological appearance. Skin biopsy specimen from lesion on back. a (HE × 4) shows nodular to diffuse infiltrate of dermis and subcutis, b (HE × 100) monomorphous vacuolated macrophages without significant atypia or atypical mitoses, sparse presence of eosinophils and sparing of papillary and periadnexal dermis (Shapiro variant of xanthogranuloma), c CD163 immunohistochemistry with strong cytoplasmic reactivity (× 100)Back to article page