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Table 6 Comparison of the frequency of VDR gene BsmI polymorphism genotypes among different age-of-onset sub-groups of Kuwaiti TIDM patients

From: Relationship of four vitamin D receptor gene polymorphisms with type 1 diabetes mellitus susceptibility in Kuwaiti children

BsmI genotype/Age of onset sub-groups

Frequency (%)

OR (95% CI)*

P-value**

bb - genotype

 < 4 years vs

7/29 (24.1)

0.84 (0.26–2.71)

1.0

 4–6 years

8/29 (27.6)

 < 4 years vs

7/29 (24.1)

0.34 (0.11–1.05)

0.10

 >  6 years

14/29 (48.3)

 4–6 years vs

8/29 (27.6)

0.41 (0.14–1.22)

0.18

 >  6 years

14/29 (48.3)

Bb-genotype

 < 4 years vs

17/83 (20.5)

0.87 (0.41–1.82)

0.85

 4–6 years

19/83 (22.9)

 < 4 years vs

17/83 (20.5)

0.20 (0.10–0.39)

< 0.0001

 >  6 years

47/83 (56.6)

 4–6 years vs

19/83 (22.9)

0.23 (0.12–0.45)

< 0.0001

 >  6 years

47/83 (56.6)

BB-genotype

 < 4 years vs

24/136 (17.6)

0.60 (0.33–1.07)

0.11

 4–6 years

36/136 (26.5)

 < 4 years vs

24/136 (17.6)

0.17 (0.20–0.30)

< 0.0001

 >  6 years

76/136 (55.9)

 4–6 years vs

36/136 (26.5)

0.28 (0.17–0.47)

< 0.0001

 >  6 years

76/136 (55.9)

  1. *OR (95% CI), odds ratio 95% confidence interval; **P-values were considered significant when < 0.05. The age-of-onset information was not available in 5 T1DM patients (data reported from 248 T1DM patients)