Relationship of four vitamin D receptor gene polymorphisms with type 1 diabetes mellitus susceptibility in Kuwaiti children

Table 5 Comparison of the frequency of VDR gene TaqI polymorphism genotypes among different age-of-onset sub-groups of Kuwaiti TIDM patients

TaqI genotype/Age of onset sub-groups	Frequency (%)	OR (95% CI)*	P-value**
CC-genotype
< 4 years vs	11/60 (18.3)	0.39 (0.17–0.90)	0.04
4–6 years	22/60 (36.7)	0.39 (0.17–0.90)	0.04
< 4 years vs	11/60 (18.3)	0.27 (0.12–0.63)	< 0.01
> 6 years	27/60 (45.0)	0.27 (0.12–0.63)	< 0.01
4–6 years vs	22/60 (36.7)	0.71 (0.34–1.47)	0.46
> 6 years	27/60 (45.0)	0.71 (0.34–1.47)	0.46
CT-genotype
< 4 years vs	22/96 (22.9)	1.29 (0.64–2.59)	0.59
4–6 years	18/96 (18.8)	1.29 (0.64–2.59)	0.59
< 4 years vs	22/96 (24.5)	0.21 (0.11–0.40)	< 0.0001
> 6 years	56/96 (58.3)	0.21 (0.11–0.40)	< 0.0001
4–6 years vs	18/96 (18.8)	0.16 (0.09–0.32)	< 0.0001
> 6 years	56/96 (58.3)	0.16 (0.09–0.32)	< 0.0001
TT -genotype
< 4 years vs	15/92 (16.3)	0.58 (0.28–1.20)	0.20
4–6 years	23/92 (25.0)	0.58 (0.28–1.20)	0.20
< 4 years vs	15/92 (16.3)	0.14 (0.07–0.27)	< 0.0001
> 6 years	54/92 (58.7)	0.14 (0.07–0.27)	< 0.0001
4–6 years vs	23/92 (25.0)	0.23 (0.13–0.44)	< 0.0001
> 6 years	54/92 (58.7)	0.23 (0.13–0.44)	< 0.0001

*OR (95% CI), odds ratio 95% confidence interval; **P-values were considered significant when < 0.05. The age-of-onset information was not available in 5 T1DM patients (data reported from 248 T1DM patients)

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