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Table 4 Comparison of the frequency of VDR gene Apal polymorphism genotypes among different age-of-onset sub-groups of Kuwaiti TIDM patients

From: Relationship of four vitamin D receptor gene polymorphisms with type 1 diabetes mellitus susceptibility in Kuwaiti children

ApaI Genotype/Age of onset sub-groups

Frequency (%)

OR (95% CI)*

P-value**

GG-genotype

 < 4 years vs

7/28 (25)

1.53 (0.42–5.57)

0.74

 4–6 years

5/28 (18)

 < 4 years vs

7/28 (25)

0.25 (0.08–0.77)

0.02

 >  6 years

16/28 (57)

 4–6 years vs

5/28 (18)

0.16 (0.04–0.55)

0.005

 >  6 years

16/28 (57)

GT-genotype

 < 4 years vs

7/31 (22.6)

1.22 (0.36–4.14)

1.0

 4–6 years

6/31 (19.4)

 < 4 years vs

7/31 (22.6)

0.21 (0.07–0.64)

< 0.01

 >  6 years

18/31 (58.0)

 4–6 years vs

6/31 (19.4)

0.17 (0.06–0.54)

< 0.01

 >  6 years

18/31 (58.0)

TT-genotype

 < 4 years vs

34/188 (18.0)

0.58 (0.35–0.94)

0.04

 4–6 years

52/188 (27.7)

 < 4 years vs

34/188 (18.0)

0.19 (0.12–0.30)

< 0.0001

 >  6 years

102/188 (54.3)

 4–6 years vs

52/188 (27.7)

0.32 (0.21–0.50)

< 0.0001

 >  6 years

102/188 (54.3)

  1. *OR (95% CI), odds ratio 95% confidence interval; **P-values were considered significant when < 0.05. The age-of-onset information was not available in 5 T1DM patients (data available from 248 T1DM patients). In one T1DM patient the ApaI genotype could not be determined, therefore data reported from 247 cases