Relationship of four vitamin D receptor gene polymorphisms with type 1 diabetes mellitus susceptibility in Kuwaiti children

Table 3 Comparison of the genotype frequency of VDR gene FokI polymorphism among different age-of-onset subgroups of Kuwaiti T1DM patients

FokI Genotype/Age of onset sub-groups	Frequency (%)	OR (95% CI)*	P-value**
ff-genotype
< 4 years vs	33/174 (19.0)	0.74 (0.44–1.23)	0.30
4–6 years	42/174 (24.1)	0.74 (0.44–1.23)	0.30
< 4 years vs	33/174 (19.0)	0.18 (0.11–0.29)	< 0.0001
> 6 years	99/174 (56.9)	0.18 (0.11–0.29)	< 0.0001
4–6 years vs	42/174 (24.1)	0.24 (0.15–0.38)	< 0.0001
> 6 years	99/174 (56.9)	0.24 (0.15–0.38)	< 0.0001
Ff-genotype
< 4 years vs	7/30 (23.3)	1.0 (0.30–3.30)	1
4–6 years	7/30 (23.3)	1.0 (0.30–3.30)	1
< 4 years vs	7/30 (23.3)	0.27 (0.09–0.80)	0.03
> 6 years	16/30 (53.4)	0.27 (0.09–0.80)	0.03
4–6 years vs	7/30 (23.3)	0.27 (0.09–0.80)	0.03
> 6 years	16/30 (53.4)	0.27 (0.09–0.80)	0.03
FF-genotype
< 4 years vs	8/44 (18.2)	0.48 (0.18–1.29)	0.21
4–6 years	14/44 (31.8)	0.48 (0.18–1.29)	0.21
< 4 years vs	8/44 (18.2)	0.22 (0.08–0.58)	< 0.01
> 6 years	22/44 (50.0)	0.22 (0.08–0.58)	< 0.01
4–6 years vs	14/44 (31.8)	0.47 (0.20–1.11)	0.13
> 6 years	22/44 (50.0)	0.47 (0.20–1.11)	0.13

*OR (95% CI), odds ratio 95% confidence interval; **P-values were considered significant when < 0.05. The age-of-onset information was not available in 5 T1DM patients (data reported from 248 T1DM patients)

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