Relationship of four vitamin D receptor gene polymorphisms with type 1 diabetes mellitus susceptibility in Kuwaiti children

Table 1 Comparison of the genotype and allele frequency of VDR gene polymorphisms (FokI, and TaqI) between Kuwaiti T1DM patients and controls

VDR gene polymorphism	Patients N (%)	Control N* (%)	OR (95% CI)**	P–value***
FokI
Co-dominant	N = 253	N = 214
FF	45 (17.8)	146 (68.2)	1.00 (Reference)^a
Ff	30 (11.9)	1 (0.5)	97.3 (12.90–73.24)	< 0.0001
ff	178 (70.3)	67 (31.3)	8.62 (5.57–13.35)	< 0.0001
Dominant
FF	45 (17.8)	146 (68.2)	1.00 (Reference)^a
Ff/ff (Ff + ff)	208 (82.2)	68 (31.8)	9.92 (6.44–15.28)	< 0.0001
Alleles	N = 506	N = 428
F	120 (23.7)	293 (68.51)	1.00 (Reference)^a
f	386 (76.3)	135 (31.5)	6.98 (5.23–9.3)	< 0.0001
TaqI	N = 253	N = 214
Co-dominant
TT	96 (38)	156 (73)	1.00 (Reference)^a
TC	96 (38)	36 (17)	4.3 (2.73–6.86)	< 0.0001
CC	61 (24)	22 (10)	4.51 (2.60–7.81)	< 0.0001
Dominant
TT	96 (38)	156 (73)	1.00 (Reference)^a
TC/CC (TC + CC)	157 (76)	58 (27)	4.39 (2.96–6.52)	< 0.0001
Alleles	N = 506	N = 428
T	288 (56.9)	348 (81.3)	1.00 (Reference)^a
C	218 (43.1)	80 (18.9)	3.29 (2.44–4.45)	< 0.0001

*N number of subjects, **OR Odds ratio, 95% CI Confidence interval, ***P-values were considered significant when < 0.05. ^aFor details please see the Methods section

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